ArticleJournal of neurology2023
Mortality risk in adults with intellectual disabilities and epilepsy: an England and Wales case-control study.
Article in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- The Effect of SPECTROM Training on Support Staff Knowledge of Psychotropic Medicine and Attitude Towards Behaviours That Challenge in Adults With Intellectual Disabilities to Help Implement the STOMP Initiative.Journal of intellectual disability research : JIDR · 2025Trial
- Holistic management of epilepsy in adults with intellectual development disorders.Epileptic disorders : international epilepsy journal with videotape · 2026Article
- A Rapid Mapping Review of Medication Burden in Adults with an Intellectual Disability: What We Know and What We Do Not Know.Drug, healthcare and patient safety · 2026Review
- The overlooked burden: anti-seizure medications, laxatives, and antipsychotics prescribed in primary care for people with intellectual disability.Frontiers in psychiatry · 2026Article
- Neuropsychiatric research databases for people with intellectual disabilities and epilepsy (REFINE): a feasibility study protocol.BMJ open · 2025Article
- Article
- Psychiatrists and non-psychiatrists' attitudes to psychotropic optimisation for people with intellectual disabilities and/or autism: cross-sectional comparison study.BJPsych open · 2025Article
- Dementia in Intellectual Disability: An Exploratory Investigation of Comorbidity Patterns and Diagnostic Outcomes.Journal of intellectual disability research : JIDR · 2025Article
- Neurologists' perspectives on SUDEP communication: A comparative study across five European countries.Epilepsia open · 2025Article
- Registered Nurse-Led Interdisciplinary Care: A Single Case Study of a Young Woman With Intellectual Disability and Chronic and Complex Health Problems.Journal of clinical nursing · 2025Article
- Outcome Measures in intellectual disability: A Review and narrative synthesis of validated instruments.The International journal of social psychiatry · 2025Review
- Treatment of Seizures in People with Intellectual Disability.CNS drugs · 2025Review
- Evidencing the challenges of care delivery for people with intellectual disability and epilepsy in England by using the Step Together toolkit.BJPsych open · 2024Article
- New valproate regulations, informed choice and seizure risk.Journal of neurology · 2024Review
- The relationship between clinical presentation and the nature of care in adults with intellectual disability and epilepsy - national comparative cohort study.BJPsych open · 2024Article
- Laxative use in adults with intellectual disabilities: development of prescribing guidelines.BJPsych open · 2024Article
- Chronic constipation in people with intellectual disabilities in the community: cross-sectional study.BJPsych open · 2024Article
- Rapid switching from levetiracetam to brivaracetam in pharmaco-resistant epilepsy in people with and without intellectual disabilities: a naturalistic case control study.Journal of neurology · 2023Article
- Cenobamate significantly improves seizure control in intellectually disabled patients with drug-resistant epilepsy and allows drug load reduction.Frontiers in neurology · 2023Article
- Improving nocturnal event monitoring in people with intellectual disability in community using an artificial intelligence camera.Epilepsy & behavior reports · 2023Article
Corrections and comments
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Authors and funding
16 authors at 12 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeople with epilepsy (PWE) and people with intellectual disabilities (ID) both live shorter lives than the general population and both conditions increase the risk of death further. We aimed to measure associations between certain risk factors for death in PWE and ID.
methodsA retrospective case-control study was conducted in ten regions in England and Wales. Data were collected on PWE registered with secondary care ID and neurology services between 2017 and 2021. Prevalence rates of neurodevelopmental, psychiatric and medical diagnoses, seizure frequency, psychotropic and antiseizure medications (ASM) prescribed, and health activity (epilepsy reviews/risk assessments/care plans/compliance etc.) recorded were compared between the two groups.
results190 PWE and ID who died were compared with 910 living controls. People who died were less likely to have had an epilepsy risk assessment but had a greater prevalence of genetic conditions, older age, poor physical health, generalized tonic-clonic seizures, polypharmacy (not ASMs) and antipsychotic use. The multivariable logistic regression for risk of epilepsy-related death identified that age over 50, medical condition prevalence, antipsychotic medication use and the lack of an epilepsy review in the last 12 months as associated with increased risk of death. Reviews by psychiatrists in ID services was associated with a 72% reduction in the odds of death compared neurology services.
conclusionsPolypharmacy and use of antipsychotics may be associated with death but not ASMs. Greater and closer monitoring by creating capable health communities may reduce the risk of death. ID services maybe more likely to provide this holistic approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.