Evidence map›Paper›PMID 37022437›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2023

Glucose-conjugated glutenin nanoparticles for selective targeting and delivery of camptothecin into breast cancer cells.

Raja Rajeswari Rajeshkumar, Parasuraman Pavadai, Theivendren Panneerselvam, Venkataraman Deepak, Sureshbabu Ram Kumar Pandian, Shanmugampillai Jeyarajaguru Kabilan, Sivakumar Vellaichamy, Anbu Jeyaraman, A Santhana Krishna Kumar, Krishnan Sundar and 1 more

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Raja Rajeswari RajeshkumarDepartment of Biotechnology, Kalasalingam Academy of Research and Education, Krishnankoil, Virudhunagar, 626126, India.
Parasuraman PavadaiDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bengaluru, 560054, India.
Theivendren PanneerselvamDepartment of Pharmaceutical Chemistry, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Namakkal, 637205, India.
Venkataraman DeepakDepartment of Biotechnology, Kalasalingam Academy of Research and Education, Krishnankoil, Virudhunagar, 626126, India.
Sureshbabu Ram Kumar PandianDepartment of Biotechnology, Kalasalingam Academy of Research and Education, Krishnankoil, Virudhunagar, 626126, India.
Shanmugampillai Jeyarajaguru KabilanDepartment of Biotechnology, Kalasalingam Academy of Research and Education, Krishnankoil, Virudhunagar, 626126, India.
Sivakumar VellaichamyDepartment of Pharmaceutics, Arulmigu Kalasalingam College of Pharmacy, Krishnankoil, Virudhunagar, 626126, India.
Anbu JeyaramanDepartment of Pharmacology, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bengaluru, 560054, India.
A Santhana Krishna KumarDepartment of Chemistry, National Sun Yat-Sen University, Gushan District, No. 70, Lien-Hai Road, Kaohsiung, 80424, Taiwan.
Krishnan SundarDepartment of Biotechnology, Kalasalingam Academy of Research and Education, Krishnankoil, Virudhunagar, 626126, India.
Selvaraj KunjiappanDepartment of Biotechnology, Kalasalingam Academy of Research and Education, Krishnankoil, Virudhunagar, 626126, India. selvapharmabio@gmail.com.
Kalasalingam Academy of Research and Education · INM S Ramaiah University of Applied Sciences · INNational Sun Yat-sen University · TWSwami Vivekanand College of Pharmacy · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Receptor-mediated drug delivery systems are a promising tool for targeting malignant cells to suppress/inhibit the malignancy without disturbing healthy cells. Protein-based nanocarrier systems possess numerous advantages for the delivery of variety of chemotherapeutics, including therapeutic peptides and genes. In the present work, glucose-conjugated camptothecin-loaded glutenin nanoparticles (Glu-CPT-glutenin NPs) were fabricated to deliver camptothecin to MCF-7 cells via GLUT-1 transporter protein. Initially, Glu-conjugated glutenin polymer was successfully synthesized through reductive amination reaction, and this was confirmed by FTIR and

Indexed as

Breast NeoplasmsNanoparticlesCamptothecinCell Line, TumorDrug Delivery SystemsFemaleGlutensHumansMCF-7 CellsPolymersCamptothecingluteninGlutensPolymersCamptothecinGlucoseGLUT-1GluteninMCF-7 cellsTargeted drug delivery

Identifiers

PMID37022437
OpenAlexW4362658196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.