Evidence map›Paper›PMID 37022173›Full record

ArticleMicrobiology spectrum2023

Contribution of the Oral and Gastrointestinal Microbiomes to Bloodstream Infections in Leukemia Patients.

Stephanie McMahon, Pranoti Sahasrabhojane, Jiwoong Kim, Samantha Franklin, Chia-Chi Chang, Robert R Jenq, Andrew E Hillhouse, Samuel A Shelburne, Jessica Galloway-Peña

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 23 citations in OpenAlex.

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  17. Pathogens (Basel, Switzerland) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Stephanie McMahonInterdisciplinary Genetics Program, Texas A&M University, College Station, Texas, USA.
Pranoti SahasrabhojaneDepartment of Infectious Diseases, Infection Control, and Employee Health, MD Anderson Cancer Center, Houston, Texas, USA.
Jiwoong KimDepartment of Bioinformatics and Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Samantha FranklinInterdisciplinary Genetics Program, Texas A&M University, College Station, Texas, USA.
Chia-Chi ChangDepartment of Genomic Medicine, MD Anderson Cancer Center, Houston, Texas, USA.
Robert R JenqDepartment of Genomic Medicine, MD Anderson Cancer Center, Houston, Texas, USA.
Andrew E HillhouseDepartment of Veterinary Pathobiology, Texas A&M University, College Station, Texas, USA.
Samuel A ShelburneDepartment of Infectious Diseases, Infection Control, and Employee Health, MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0001-9721-263X
Jessica Galloway-PeñaInterdisciplinary Genetics Program, Texas A&M University, College Station, Texas, USA.ORCID 0000-0003-1081-254X
The University of Texas MD Anderson Cancer Center · USTexas A&M University · USThe University of Texas Southwestern Medical Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Protecting colonic mucus to mitigate acute intestinal graft-versus-host diseaseR01HL124112 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI JENQ, ROBERT · 2015 to 2024
$6.8M
Identifying Risk Factors for Antibiotic Resistance via Integration of Epidemiology and MetagenomicsK01AI143881 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GALLOWAY-PENA, JESSICA RHEA · 2019 to 2023
$545k
NCI NIH HHS P30 CA016672NHLBI NIH HHS R01 HL124112NIAID NIH HHS K01 AI143881
6 · The paper itself

Abstract

Bloodstream infections (BSIs) pose a significant mortality risk for acute myeloid leukemia (AML) patients. It has been previously reported that intestinal domination (>30% relative abundance [RA] attributed to a single taxon) with the infecting taxa often precedes BSI in stem cell transplant patients. Using 16S rRNA amplicon sequencing, we analyzed oral and stool samples from 63 AML patients with BSIs to determine the correlation between the infectious agent and microbiome composition. Whole-genome sequencing and antimicrobial susceptibilities were performed on all BSI isolates. Species-level detection of the infectious agent and presence of antibiotic resistance determinants in the stool (

Indexed as

BacteremiaGastrointestinal MicrobiomeLeukemia, Myeloid, AcuteMicrobiotaAnti-Bacterial AgentsHumansRNA, Ribosomal, 16SAnti-Bacterial AgentsRNA, Ribosomal, 16Sbacteremiacolonizationintestinal dominationleukemiaoral microbiome

Identifiers

PMID37022173
PMCPMC10269818
OpenAlexW4362658272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.