Evidence map›Paper›PMID 37022158›Full record

ArticlemBio2023

Antagonistic Mobile Genetic Elements Can Counteract Each Other's Effects on Microbial Community Composition.

Meaghan Castledine, Arthur Newbury, Rai Lewis, Christian Hacker, Sean Meaden, Angus Buckling

Open access · goldAbstract read
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Global Antimicrobial Resistance Gene Study ofAntibiotics (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Meaghan CastledineCollege of Life and Environmental Sciences, Environment and Sustainability Institute, University of Exeter, Penryn, United Kingdom.ORCID 0000-0001-5752-2641
Arthur NewburyCollege of Life and Environmental Sciences, Environment and Sustainability Institute, University of Exeter, Penryn, United Kingdom.ORCID 0000-0002-5144-8249
Rai LewisCollege of Life and Environmental Sciences, Environment and Sustainability Institute, University of Exeter, Penryn, United Kingdom.
Christian HackerBioimaging Center, College of Life and Environmental Sciences, University of Exeter, Exeter, United Kingdom.ORCID 0000-0003-4920-9289
Sean MeadenCollege of Life and Environmental Sciences, Environment and Sustainability Institute, University of Exeter, Penryn, United Kingdom.ORCID 0000-0002-9748-6937
Angus BucklingCollege of Life and Environmental Sciences, Environment and Sustainability Institute, University of Exeter, Penryn, United Kingdom.ORCID 0000-0003-1170-4604
University of Exeter · GB

Funding

Medical Research Council MR/N0137941/1
6 · The paper itself

Abstract

Bacteriophages ("phages") are hypothesized to be key drivers of bacterial population dynamics, driving microbial community composition, but empirical support for this is mixed. One reason why phages may have a less-than-expected impact on community composition is that many different phages and other mobile genetic elements (MGEs) interact with each bacterium. For instance, the same phage may have higher or lower costs to different bacterial strains or species. Assuming that resistance or susceptibility to MGE infection is not consistent across all MGEs, a simple prediction is that the net effect of MGEs on each bacterial taxon may converge with an increasing number of interactions with different MGEs. We formalized this prediction using

Indexed as

BacteriophagesMicrobiotaBacteriaInterspersed Repetitive SequencesPlasmidsbacteriophagesindirect interactions“kill the winner” dynamicsmicrobial communitiesmobile genetic elementsplasmids

Identifiers

PMID37022158
PMCPMC10127636
OpenAlexW4362658171

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.