ArticleThe EMBO journal2023
TOR acts as a metabolic gatekeeper for auxin-dependent lateral root initiation in Arabidopsis thaliana.
Article in The EMBO journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Machine learning-guided multi-omics suggests iron-dependent hormonal signaling drives root morphological plasticity in wheat under temperature stress.The New phytologist · 2026Article
- Duet between sugars and hormones: The molecular dialogue fine-tuning hypoxia acclimation in plants.Journal of integrative plant biology · 2026Review
- Structural Features of Root Cells ofInternational journal of molecular sciences · 2026Article
- Reducing recalcitrance of black pepper toHorticulture research · 2026Article
- The rice cysteine protease OsEP3A promotes seedling growth and seed development and contains a nitrogen-starvation-responsive sequence.Plant cell reports · 2026Article
- Molecular mechanisms of root expansion in medicinal plants.Frontiers in plant science · 2026Review
- Decoding the sugar-strigolactone crosstalk: new frontier in plant growth and stress resilience.Horticulture research · 2026Article
- Article
- Hydrogen sulfide promotes lateral root formation in peach through persulfidation of SnRK1α kinase.Plant biotechnology journal · 2025Article
- Characterization of the cyclic dipeptide cyclo(His-Pro) in Arabidopsis.Plant physiology · 2025Article
- The white lupin trehalase gene LaTRE1 regulates cluster root formation and function under phosphorus deficiency.Plant physiology · 2024Article
- Shaping root architecture: towards understanding the mechanisms involved in lateral root development.Biology direct · 2024Review
- Multi-scale mechanisms driving root regeneration: From regeneration competence to tissue repatterning.The Plant journal : for cell and molecular biology · 2024Review
- 40S Ribosomal protein S6 kinase integrates daylength perception and growth regulation in Arabidopsis thaliana.Plant physiology · 2024Article
- The critical roles of three sugar-related proteins (HXK, SnRK1, TOR) in regulating plant growth and stress responses.Horticulture research · 2024Article
- Root branching under high salinity requires auxin-independent modulation of LATERAL ORGAN BOUNDARY DOMAIN 16 function.The Plant cell · 2024Article
- Trehalose-6-phosphate signaling regulates lateral root formation in Arabidopsis thaliana.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- SNF1-RELATED KINASE 1 and TARGET OF RAPAMYCIN control light-responsive splicing events and developmental characteristics in etiolated Arabidopsis seedlings.The Plant cell · 2023Article
- TOR acts as a metabolic gatekeeper for auxin-dependent lateral root initiation in Arabidopsis thaliana.The EMBO journal · 2023Article
- Systemic control of plant regeneration and wound repair.The New phytologist · 2023Review
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Authors and funding
14 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant organogenesis requires matching the available metabolic resources to developmental programs. In Arabidopsis, the root system is determined by primary root-derived lateral roots (LRs), and adventitious roots (ARs) formed from non-root organs. Lateral root formation entails the auxin-dependent activation of transcription factors ARF7, ARF19, and LBD16. Adventitious root formation relies on LBD16 activation by auxin and WOX11. The allocation of shoot-derived sugar to the roots influences branching, but how its availability is sensed for LRs formation remains unknown. We combine metabolic profiling with cell-specific interference to show that LRs switch to glycolysis and consume carbohydrates. The target-of-rapamycin (TOR) kinase is activated in the lateral root domain. Interfering with TOR kinase blocks LR initiation while promoting AR formation. The target-of-rapamycin inhibition marginally affects the auxin-induced transcriptional response of the pericycle but attenuates the translation of ARF19, ARF7, and LBD16. TOR inhibition induces WOX11 transcription in these cells, yet no root branching occurs as TOR controls LBD16 translation. TOR is a central gatekeeper for root branching that integrates local auxin-dependent pathways with systemic metabolic signals, modulating the translation of auxin-induced genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.