Evidence map›Paper›PMID 37021413›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2023

Predictors of Adherence to Continuous Positive Airway Pressure in Older Adults With Apnea and Amnestic Mild Cognitive Impairment.

Kathy C Richards, Alicia J Lozano, Jennifer Morris, Stephen T Moelter, Wenyan Ji, Vani Vallabhaneni, Yanyan Wang, Luqi Chi, Eric M Davis, Cindy Cheng and 6 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06773416 (Treating Sleep Apnea to Improve Cognitive Function, Alzheimer's Disease Pathology, and Astrocyte Activation in Older Adults With Cognitive Impairment), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06773416 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Treating Sleep Apnea to Improve Cognitive Function, Alzheimer's Disease Pathology, and Astrocyte Activation in Older Adults With Cognitive Impairment: A Multi-Centre Randomized Controlled Trial

TypeinterventionalSponsorSunnybrook Health Sciences CentreRan2025 to 2028Enrolled206ConditionsObstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI), Cognitive Decline Prevention in Pre-frail Older AdultsArmsCPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health, Delayed CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 2 countries.

Kathy C RichardsSchool of Nursing, University of Texas at Austin, Austin, Texas, USA.
Alicia J LozanoDepartment of Statistics, Center for Biostatistics and Health Data Science, Virginia Tech, Roanoke, Virginia, USA.
Jennifer MorrisDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Stephen T MoelterDepartment of Psychology, Saint Joseph's University, Philadelphia, Pennsylvania, USA.
Wenyan JiDepartment of Statistics, Center for Biostatistics and Health Data Science, Virginia Tech, Roanoke, Virginia, USA.
Vani VallabhaneniSleep 360, Austin, Texas, USA.
Yanyan WangNational Clinical Research Center for Geriatrics & Nursing Key Laboratory of Sichuan Province, West China Hospital & West China School of Medicine, Sichuan University, Chengdu, China.
Luqi ChiDepartment of Neurology, Washington University, St. Louis, Missouri, USA.
Eric M DavisDivision of Pulmonary and Critical Care, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Cindy ChengDepartment of Family and Community Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Vanessa AguilarSchool of Nursing, University of Texas at Austin, Austin, Texas, USA.
Sneha KhanDepartment of Osteopathic Medicine, Arkansas State University, Jonesboro, Arkansas, USA.
Mira SankhavaramSchool of Nursing, University of Texas at Austin, Austin, Texas, USA.
Alexandra L HanlonDepartment of Statistics, Center for Biostatistics and Health Data Science, Virginia Tech, Roanoke, Virginia, USA.
David A WolkDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Nalaka GooneratneDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
The University of Texas at Austin · USUniversity of Pennsylvania · USVirginia Tech · USArkansas State University · USSaint Joseph's University · USSichuan University · CNThomas Jefferson University · USUniversity of Virginia · USWashington University in St. Louis · US

Funding

Changing the Trajectory of Mild Cognitive Impairment with CPAP Treatment of Obstructive Sleep ApneaR01AG054435 · NIA · UNIVERSITY OF PENNSYLVANIA · PI GOONERATNE, NALAKA S, WOLK, DAVID A · 2017 to 2020
$10.3M
Mild Cognitive Impairment and Obstructive Sleep ApneaR01AG034682 · NIA · GEORGE MASON UNIVERSITY · PI RICHARDS, KATHY CULPEPPER · 2011 to 2013
$1.8M
NIA NIH HHS R01 AG034682NIA NIH HHS R01 AG054435
6 · The paper itself

Abstract

backgroundAlmost 60% of adults with amnestic mild cognitive impairment (aMCI) have obstructive sleep apnea (OSA). Treatment with continuous positive airway pressure (CPAP) may delay cognitive decline, but CPAP adherence is often suboptimal. In this study, we report predictors of CPAP adherence in older adults with aMCI who have increased odds of progressing to dementia, particularly due to Alzheimer's disease.

methodsThe data are from Memories 2, "Changing the Trajectory of Mild Cognitive Impairment with CPAP Treatment of Obstructive Sleep Apnea." Participants had moderate to severe OSA, were CPAP naïve, and received a telehealth CPAP adherence intervention. Linear and logistic regression models examined predictors.

resultsThe 174 participants (mean age 67.08 years, 80 female, 38 Black persons) had a mean apnea-hypopnea index of 34.78, and 73.6% were adherent, defined as an average of ≥4 hours of CPAP use per night. Only 18 (47.4%) Black persons were CPAP adherent. In linear models, White race, moderate OSA, and participation in the tailored CPAP adherence intervention were significantly associated with higher CPAP use at 3 months. In logistic models, White persons had 9.94 times the odds of adhering to CPAP compared to Black persons. Age, sex, ethnicity, education, body mass index, nighttime sleep duration, daytime sleepiness, and cognitive status were not significant predictors.

conclusionsOlder patients with aMCI have high CPAP adherence, suggesting that age and cognitive impairment should not be a barrier to prescribing CPAP. Research is needed to improve adherence in Black patients, perhaps through culturally tailored interventions.

Indexed as

Cognitive DysfunctionSleep Apnea, ObstructiveAgedContinuous Positive Airway PressureFemaleHumansPatient ComplianceMotivational enhancementObstructive sleep apneaRaceTailored

Identifiers

PMID37021413
PMCPMC11007392
OpenAlexW4362657087

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.