Evidence map›Paper›PMID 37021193›Full record

SynthesisEuropean stroke journal2023

General anesthesia versus conscious sedation during endovascular treatment in posterior circulation large vessel occlusion: A systematic review and meta-analysis.

Mikel Terceño, Saima Bashir, Juan Cienfuegos, Alan Murillo, Víctor Augusto Vera-Monge, Laura Pardo, Montserrat Reina, Carme Gubern-Mérida, Dolors Puigoriol-Illamola, Laia Carballo and 4 more

Open access · greenAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in European stroke journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Mikel TerceñoStroke Unit, Department of Neurology, Hospital Universitari Doctor Josep Trueta de Girona, Girona, Spain.ORCID 0000-0001-5532-5329
Saima BashirStroke Unit, Department of Neurology, Hospital Universitari Doctor Josep Trueta de Girona, Girona, Spain.ORCID 0000-0002-2019-467X
Juan CienfuegosStroke Unit, Department of Neurology, Hospital Universitari Doctor Josep Trueta de Girona, Girona, Spain.
Alan MurilloStroke Unit, Department of Neurology, Hospital Universitari Doctor Josep Trueta de Girona, Girona, Spain.
Víctor Augusto Vera-MongeStroke Unit, Department of Neurology, Hospital Universitari Doctor Josep Trueta de Girona, Girona, Spain.
Laura PardoStroke Unit, Department of Neurology, Hospital Universitari Doctor Josep Trueta de Girona, Girona, Spain.
Montserrat ReinaStroke Unit, Department of Neurology, Hospital Universitari Doctor Josep Trueta de Girona, Girona, Spain.
Carme Gubern-MéridaStroke Unit, Department of Neurology, Hospital Universitari Doctor Josep Trueta de Girona, Girona, Spain.
Dolors Puigoriol-IllamolaStroke Unit, Department of Neurology, Hospital Universitari Doctor Josep Trueta de Girona, Girona, Spain.
Laia CarballoStroke Unit, Department of Neurology, Hospital Universitari Doctor Josep Trueta de Girona, Girona, Spain.
Anna CostaDepartment of Anesthesiology and Critical Care Medicine, Hospital Universitari Doctor Josep Trueta de Girona, Girona, Spain.
Maria BuxóStatistical and Methodological Department, Girona Biomedical Research Institute (IDIBGI), Girona, Spain.
Joaquín SerenaStroke Unit, Department of Neurology, Hospital Universitari Doctor Josep Trueta de Girona, Girona, Spain.
Yolanda SilvaStroke Unit, Department of Neurology, Hospital Universitari Doctor Josep Trueta de Girona, Girona, Spain.
Institut d'Investigació Biomèdica de Girona · ESHospital Universitari de Girona Doctor Josep Trueta · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: The optimal anesthetic approach in the endovascular treatment (EVT) of patients with posterior circulation large vessel occlusion (PC-LVO) strokes is not clear. Little data has been published and no randomized clinical trials have been conducted so far. We aimed to perform an updated meta-analysis to compare clinical and procedural outcomes between conscious sedation (CS) and general anesthesia (GA). Methods: We reviewed the literature of the studies reporting CS and GA in patients with endovascularly-treated PC-LVO. The primary outcome was the functional outcome at 3 months measured using the modified Rankin Scale (mRS). A good functional outcome was defined as having a mRS 0-2. Secondary outcomes were mortality at 3 months, final successful recanalization (modified Thrombolysis in Cerebral Infarction (mTICI) scale from 2b to 3) and complete recanalization (mTICI of 3) and times from stroke onset to EVT completion. Random-effects models were completed to pool the outcomes and the Findings: Eight studies with a total of 1351 patients were included. The pooled results reveal that CS use was associated with higher rates of good outcome (OR 2.41, 95% CI 1.58-3.64, Conclusion: In this meta-analysis, GA was associated with significantly lower rates of functional independence at 3 months in patients with PC-LVO strokes.

Indexed as

Endovascular ProceduresStrokeAnesthesia, GeneralCerebral InfarctionHumansProcedural SedationTreatment Outcomeconscious sedationendovascular treatmentgeneral anesthesiaMeta-analysisposterior circulation-large vessel occlusion

Identifiers

PMID37021193
PMCPMC10069205
OpenAlexW4306157905

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.