Evidence map›Paper›PMID 37021176›Full record

ArticleEuropean stroke journal2023

European Stroke Organisation (ESO) Guidelines on Moyamoya angiopathy Endorsed by Vascular European Reference Network (VASCERN).

Anna Bersano, Nadia Khan, Blanca Fuentes, Francesco Acerbi, Isabella Canavero, Elisabeth Tournier-Lasserve, Peter Vajcoczy, Maria Luisa Zedde, Salman Hussain, Sabrina Lémeret and 2 more

Open access · greenAbstract read
In one paragraph

Article in European stroke journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 4 pooled it
17.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 4 syntheses or guidelines pooled it, 70 citations in OpenAlex.

  1. Pooled it
  2. Guideline
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  4. Pooled it
  5. Trial
  6. Article
  7. Article
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  11. ALIGNED Network for rare cerebrovascular diseases: methodology and preliminary results.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  12. Article
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  15. An Overview of Genetics of Moyamoya: BeyondInternational journal of molecular sciences · 2026
    Review
  16. Article
  17. Article
  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 7 countries.

Anna BersanoCerebrovascular Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.ORCID 0000-0002-2493-628X
Nadia KhanMoyamoya Center, University Children's Hospital Zurich, Switzerland.
Blanca FuentesDepartment of Neurology and Stroke Center, Hospital La Paz Institute for Health Research-IdiPAZ (La Paz University Hospital-Universidad Autónoma de Madrid), Madrid, Spain.ORCID 0000-0002-0363-862X
Francesco AcerbiCerebrovascular Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Isabella CanaveroCerebrovascular Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Elisabeth Tournier-LasserveINSERM U1141, Hôspital Robert Debré, Paris, France.
Peter VajcoczyDepartment of Neurosurgery, Charité Universitätsmedizin Berlin, Germany.
Maria Luisa ZeddeNeurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Italy.
Salman HussainEuropean Stroke Organisation, Basel, Switzerland.
Sabrina LémeretEuropean Stroke Organisation, Basel, Switzerland.ORCID 0000-0001-8611-1630
Markus KraemerDepartment of Neurology, Alfried Krupp Hospital, Essen, Germany.
Dominique HerveCNVT-CERVCO et département de Neurologie, Hôpital Lariboisière, APHP Nord, Paris, France.
Fondazione IRCCS Istituto Neurologico Carlo Besta · ITEuropean CanCer Organisation · BEAlfried Krupp Hospital · DEAssistance Publique – Hôpitaux de Paris · FRAzienda Sanitaria Unità Locale di Reggio Emilia · ITCharité - Universitätsmedizin Berlin · DEHospital La Paz Institute for Health Research · ESInserm · FRSurya University · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The European Stroke Organisation (ESO) guidelines on Moyamoya Angiopathy (MMA), developed according to ESO standard operating procedure and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methodology, were compiled to assist clinicians in managing patients with MMA in their decision making. A working group involving neurologists, neurosurgeons, a geneticist and methodologists identified nine relevant clinical questions, performed systematic literature reviews and, whenever possible, meta-analyses. Quality assessment of the available evidence was made with specific recommendations. In the absence of sufficient evidence to provide recommendations, Expert Consensus Statements were formulated. Based on low quality evidence from one RCT, we recommend direct bypass surgery in adult patients with haemorrhagic presentation. For ischaemic adult patients and children, we suggest revascularization surgery using direct or combined technique rather than indirect, in the presence of haemodynamic impairment and with an interval of 6-12 weeks between the last cerebrovascular event and surgery. In the absence of robust trial, an Expert Consensus was reached recommending long-term antiplatelet therapy in non-haemorrhagic MMA, as it may reduce risk of embolic stroke. We also agreed on the utility of performing pre- and post- operative haemodynamic and posterior cerebral artery assessment. There were insufficient data to recommend systematic variant screening of RNF213 p.R4810K. Additionally, we suggest that long-term MMA neuroimaging follow up may guide therapeutic decision making by assessing the disease progression. We believe that this guideline, which is the first comprehensive European guideline on MMA management using GRADE methods will assist clinicians to choose the most effective management strategy for MMA.

Indexed as

Embolic StrokeMoyamoya DiseaseStrokeAdenosine TriphosphatasesAdultChildDisease ProgressionHumansUbiquitin-Protein LigasesAdenosine TriphosphatasesRNF213 protein, humanUbiquitin-Protein LigasesdiagnosisguidelinesMoyamoya angiopathystrokesystematic reviewtherapy

Identifiers

PMID37021176
PMCPMC10069176
OpenAlexW4318977081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.