ArticleEuropean stroke journal2023
RCT versus real-world cohorts: Differences in patient characteristics drive associations with outcome after EVT.
Article in European stroke journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations between basic physiological observations recorded pre-thrombectomy and functional outcome: a systematic review and meta-analysis.Frontiers in stroke · 2023Pooled it
- Do scoring systems help us to estimate prognosis after mechanical thrombectomy? Data from the German Stroke Registry.Journal of neurointerventional surgery · 2026Article
- Formal and Informal Care Utilization in Mild Cognitive Impairment and Mild Dementia due to Alzheimer's Disease: Cross-Sectional and Longitudinal Analyses of RUD-Lite Data from the Tauriel Study.Dementia and geriatric cognitive disorders · 2025Article
- Mortality within three months after nonfatal ischemic stroke treated by mechanical thrombectomy in routine care-data from the German Stroke Registry.Neurological research and practice · 2025Article
- Perioperative Events Following Open Versus Endovascular Revascularization for Chronic Limb-Threatening Ischemia: An NSQIP Analysis.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Article
- Outcomes and risk factors for infection after endovascular treatment in patients with acute ischemic stroke.CNS neuroscience & therapeutics · 2024Article
- Associations of diabetes status and glucose measures with outcomes after endovascular therapy in patients with acute ischemic stroke: an analysis of the nationwide TREAT-AIS registry.Frontiers in neurology · 2024Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The selection of patients with large-vessel occlusion (LVO) stroke for endovascular treatment (EVT) depends on patient characteristics and procedural metrics. The relation of these variables to functional outcome after EVT has been assessed in numerous datasets from both randomized controlled trials (RCT) and real-world registries, but whether differences in their case mix modulate outcome prediction is unknown. Methods: We leveraged data from individual patients with anterior LVO stroke treated with EVT from completed RCTs from the Virtual International Stroke Trials Archive ( Results: Ten out of 11 analyzed baseline variables differed between the RCT and real-world cohort: RCT patients were younger, had higher admission NIHSS scores, and received thrombolysis more often (all Conclusions: RCT and real-world cohorts considerably differ in patient characteristics, individual outcome predictor strength, and overall outcome prediction model performance.
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