Evidence map›Paper›PMID 37021156›Full record

Observational studyEuropean stroke journal2023

Age of onset of cerebral venous thrombosis: the BEAST study.

Redoy Ranjan, Gie Ken-Dror, Ida Martinelli, Elvira Grandone, Sini Hiltunen, Erik Lindgren, Maurizio Margaglione, Veronique Le Cam Duchez, Aude Bagan Triquenot, Marialuisa Zedde and 34 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European stroke journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Review
  5. Article
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  7. Observational
  8. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors.

Redoy RanjanInstitute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK.ORCID 0000-0003-1927-5023
Gie Ken-DrorInstitute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK.
Ida MartinelliFondazione IRCCS Ca'Granda - Ospedale Maggiore Policlinico, A. Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy.
Elvira GrandoneAtherosclerosis and Thrombosis Unit, I.R.C.C.S. Home for the Relief of Suffering, S. Giovanni Rotondo, Foggia, Italy.
Sini HiltunenDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Erik LindgrenDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Maurizio MargaglioneMedical Genetics, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Veronique Le Cam DuchezNormandy University, UNIROUEN, INSERM U1096, Rouen University Hospital, Vascular Hemostasis Unit and INSERM CIC-CRB 1404, Rouen, France.
Aude Bagan TriquenotDepartment of Neurology, Rouen University Hospital, Rouen, France.
Marialuisa ZeddeNeurology Unit, Stroke Unit, Local Health Unit - Authority IRCCS of Reggio Emilia, Reggio Emilia, Italy.
Michelangelo MancusoDepartment of Clinical and Experimental Medicine, Neurological Institute, University of Pisa, Pisa, Italy.
Ynte M RuigrokUMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID 0000-0002-5396-2989
Brad WorrallDepartment of Neurology, University of Virginia, Charlottesville, VA, USA.
Jennifer J MajersikDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.
Jukka PutaalaDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Elena HaapaniemiDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Susanna M ZuurbierDepartment of Neurology, Amsterdam University Medical Centers, Location AMC, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The Netherlands.
Matthijs C BrouwerDepartment of Neurology, Amsterdam University Medical Centers, Location AMC, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The Netherlands.
Serena M PassamontiFondazione IRCCS Ca'Granda - Ospedale Maggiore Policlinico, A. Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy.
Maria AbbattistaFondazione IRCCS Ca'Granda - Ospedale Maggiore Policlinico, A. Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy.
Paolo BucciarelliFondazione IRCCS Ca'Granda - Ospedale Maggiore Policlinico, A. Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy.ORCID 0000-0003-0877-365X
Robin LemmensDepartment of Neurosciences, Experimental Neurology, KU Leuven-University of Leuven, Leuven, Belgium.
Emanuela PappalardoDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.
Paolo CostaDepartment of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, Italy.
Marina ColombiDepartment of Molecular and Translational Medicine, Division of Biology and Genetics, University of Brescia, Brescia, Italy.
Diana Aguiar de SousaStroke Center, Lisbon Central University Hospital, Lisbon, Portugal.ORCID 0000-0002-6702-7924
Sofia RodriguesDepartment of Neurosciences, Hospital of Santa Maria, University of Lisbon, Lisbon, Portugal.
Patrícia CanhaoDepartment of Neurosciences, Hospital of Santa Maria, University of Lisbon, Lisbon, Portugal.
Aleksander TkachDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.
Rosa SantacroceMedical Genetics, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Giovanni FavuzziAtherosclerosis and Thrombosis Unit, I.R.C.C.S. Home for the Relief of Suffering, S. Giovanni Rotondo, Foggia, Italy.
Antonio ArauzStroke Clinic, National Institute of Neurology and Neurosurgery Manuel Velasco Suarez, Mexico City, Mexico.
Donatella ColaizzoAtherosclerosis and Thrombosis Unit, I.R.C.C.S. Home for the Relief of Suffering, S. Giovanni Rotondo, Foggia, Italy.
Kostas SpengosDepartment of Neurology, University of Athens School of Medicine, Eginition Hospital, Athens, Greece.
Amanda HodgeMcMaster University, Pathology and Molecular Medicine, Population Health Research Institute and Thrombosis and Atherosclerosis Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada.
Reina DittaMcMaster University, Pathology and Molecular Medicine, Population Health Research Institute and Thrombosis and Atherosclerosis Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada.
Thang S HanInstitute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK.
Alessandro PezziniDepartment of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, Italy.
Jonathan M CoutinhoDepartment of Neurology, Amsterdam University Medical Centers, Location AMC, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The Netherlands.
Vincent ThijsStroke Division, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, VIC, Australia.ORCID 0000-0002-6614-8417
Katarina JoodDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Turgut TatlisumakDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
José M FerroInstituto de Medicina Molecular João Lobo Antunes, Universidade de Lisboa, Lisboa, Portugal.
Pankaj SharmaInstitute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK.

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
The NINDS International Stroke Genetics Consortium StudyU01NS069208 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KITTNER, STEVEN J · 2010 to 2013
$9.4M
Genetics of ischemic stroke in the SiGN ConsortiumR01NS100178 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KITTNER, STEVEN J, MITCHELL, BRAXTON D · 2017 to 2021
$3.0M
Genetics of Early-Onset Ischemic Stroke ConsortiumR01NS105150 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KITTNER, STEVEN J, MITCHELL, BRAXTON D · 2018 to 2022
$3.0M
Department of HealthNCATS NIH HHS UL1 TR002538NINDS NIH HHS R01 NS100178NINDS NIH HHS R01 NS105150NINDS NIH HHS U01 NS069208
6 · The paper itself

Abstract

Background: Cerebral venous thrombosis (CVT) is an uncommon cause of stroke in young adults. We aimed to determine the impact of age, gender and risk factors (including sex-specific) on CVT onset. Methods: We used data from the BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis), a multicentre multinational prospective observational study on CVT. Composite factors analysis (CFA) was performed to determine the impact on the age of CVT onset in males and females. Results: A total of 1309 CVT patients (75.3% females) aged ⩾18 years were recruited. The overall median (IQR-interquartile range) age for males and females was 46 (35-58) years and 37 (28-47) years ( Conclusions: Women suffer CVT 9 years earlier in comparison to men. Female patients with multiple (⩾1) risk factors suffer CVT ~12 years earlier compared to those with no identifiable risk factors.

Indexed as

Intracranial ThrombosisVenous ThrombosisAgedAge of OnsetFemaleHumansMaleMiddle AgedPregnancyRisk FactorsYoung Adultage of onsetcerebral venous sinus thrombosisCerebral venous thrombosiswomen

Identifiers

PMID37021156
PMCPMC10069208

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.