ArticleEuropean stroke journal2023
Comparative analysis of core and perfusion lesion volumes between commercially available computed tomography perfusion software.
Article in European stroke journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Incidence, severity and impact on functional outcome of persistent hypoperfusion despite large-vessel recanalization, a potential marker of impaired microvascular reperfusion: Systematic review of the clinical literature.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Pooled it
- Article
- Comparative Analysis of Four Commercially Available Artificial Intelligence Software for Brain Volumetry.Diagnostics (Basel, Switzerland) · 2026Article
- Preoperative volume of mildly delayed time predicts 24-hour complete reperfusion after successful mechanical thrombectomy.BMC neurology · 2026Article
- Development and Validation of a Harmonization Pipeline for Multi-Site Computed Tomography Perfusion Cerebral Blood Flow Maps-An Analysis of the AcT Trial.Clinical neuroradiology · 2026Article
- Comparison of AI-assisted quantitative collateral score and visual collateral score in stroke thrombectomy triage.Neuroradiology · 2026Article
- Beyond the numbers: what CT perfusion reveals - and what it cannot - about ischemic brain tissue.Neuroradiology · 2026Article
- Comparison of CT-perfusion software packages and validation with true infarct core in patients with acute ischemic stroke.BMC medical imaging · 2025Article
- Effect of field of view variation on CTP assessment of infarct core and penumbra in acute ischemic stroke.Scientific reports · 2025Article
- Comparative validation of automated perfusion analysis software for ischemic penumbra estimation and EVT decision-making.Frontiers in neuroscience · 2025Article
- Accuracy of computed tomography perfusion-defined ischemic core and follow-up infarction after basilar artery thrombectomy.Frontiers in neurology · 2025Article
- Automated advanced imaging in acute ischemic stroke. Certainties and uncertainties.European journal of radiology open · 2023Article
- Most endovascular thrombectomy patients have Target Mismatch despite absence of formal CT perfusion selection criteria.PloS one · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
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Abstract
Introduction: Computed tomography perfusion (CTP) imaging has become an important tool in evaluating acute recanalization treatment candidates. Large clinical trials have successfully used RAPID automated imaging analysis software for quantifying ischemic core and penumbra, yet other commercially available software vendors are also on the market. We evaluated the possible difference in ischemic core and perfusion lesion volumes and the agreement rate of target mismatch between OLEA, MIStar, and Syngo.Via versus RAPID software in acute recanalization treatment candidates. Patients and methods: All consecutive stroke-code patients with baseline CTP RAPID imaging at Helsinki University Hospital during 8/2018-9/2021 were included. Ischemic core was defined as cerebral blood flow <30% than the contralateral hemisphere and within the area of delay time (DT) >3s with MIStar. Perfusion lesion volume was defined as DT > 3 s (MIStar) and T Results: A total of 1606 patients had RAPID perfusion maps, 1222 of which had MIStar, 596 patients had OLEA, and 349 patients had Syngo.Via perfusion maps available. Each software was compared with simultaneously analyzed RAPID software. MIStar showed the smallest core difference compared with RAPID (-2 mL, confidence interval (CI) from -26 to 22), followed by OLEA (2 mL, CI from -33 to 38). Perfusion lesion volume differed least with MIStar (4 mL, CI from -62 to 71) in comparison with RAPID, followed by Syngo.Via (6 mL, CI from -94 to 106). MIStar had the best agreement rate with target mismatch of RAPID followed by OLEA and Syngo.Via. Discussion and conclusion: Comparison of RAPID with three other automated imaging analysis software showed variance in ischemic core and perfusion lesion volumes and in target mismatch.
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