ArticleExperimental and therapeutic medicine2023
Different interventions and outcomes in four teeth with regenerative endodontic procedures in the same patient: A case report with 7‑year follow‑up.
Article in Experimental and therapeutic medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 citing papers in PubMed, 0 citations in OpenAlex.
- Outcome evaluation of regenerative endodontic therapy using injectable-platelet-rich fibrin and platelet-rich fibrin in nonvital immature permanent teeth: A prospective observational study.Journal of conservative dentistry and endodontics · 2026Article
- Rare adverse root development after regenerative endodontic procedures: two case reports and contributing factors analysis.Frontiers in oral health · 2026Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
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Abstract
The present study reported on the case of a 10-year-old male patient with four second premolar teeth undergoing regenerative endodontic procedures (REPs) for periapical periodontitis due to abnormal central cusp fracture, and the follow-up over 7 years. Annual follow-up clinical and radiographic examinations were performed to assess the effectiveness of treatment. After the initial RPEs, the apical inflammation of teeth #15 and #45 disappeared and their roots continued to develop. However, teeth #25 and #35 exhibited different signs of inflammation and were treated with calcium hydroxide apexification and the second REPs, respectively. Subsequently, the narrowing of the apical foramen and healing of periapical inflammation were observed. The root of tooth #35 continued to develop but still exhibited apical inflammation. In the present case, apexification with calcium hydroxide and the second REPs were used as alternative interventions for teeth that failed after REPs. However, interventional treatment after a failure was not able to predict outcomes, necessitating a further study with a large number of cases for observational description.
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