Evidence map›Paper›PMID 37021055›Full record

ArticleFrontiers in pharmacology2023

Importance of modelling hERG binding in predicting drug-induced action potential prolongations for drug safety assessment.

Hui Jia Farm, Michael Clerx, Fergus Cooper, Liudmila Polonchuk, Ken Wang, David J Gavaghan, Chon Lok Lei

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Hui Jia FarmDepartment of Computer Science, University of Oxford, Oxford, United Kingdom.
Michael ClerxCentre for Mathematical Medicine and Biology, School of Mathematical Sciences, University of Nottingham, Nottingham, United Kingdom.
Fergus CooperDoctoral Training Centre, University of Oxford, Oxford, United Kingdom.
Liudmila PolonchukRoche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Ken WangRoche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
David J GavaghanDepartment of Computer Science, University of Oxford, Oxford, United Kingdom.
Chon Lok LeiInstitute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau, China.
University of Oxford · GBRoche (Switzerland) · CHUniversity of Macau · MOUniversity of Nottingham · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Reduction of the rapid delayed rectifier potassium current (

Indexed as

action potential predictionsdrug bindingdrug trappinghERG channelIC50 (50% inhibition concentration)mathematical modelling

Identifiers

PMID37021055
PMCPMC10067903
OpenAlexW4327978139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.