Evidence map›Paper›PMID 37020849›Full record

ArticlePeerJ2023

Leukocyte telomere length and bipolar disorder risk: evidence from Mendelian randomization analysis.

Likui Lu, Hongtao Zeng, Bangbei Wan, Miao Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Likui Lu *The First Affiliated Hospital of Soochow University, Institute for Fetology, Suzhou, Jiangsu, China.
Hongtao Zeng *The First Affiliated Hospital of Soochow University, Institute for Fetology, Suzhou, Jiangsu, China.
Bangbei WanHainan Women and Children's Medical Center, Reproductive Medical Center, Haikou, Hainan, China.
Miao SunThe First Affiliated Hospital of Soochow University, Institute for Fetology, Suzhou, Jiangsu, China.
First Affiliated Hospital of Soochow University · CNHainan Medical University · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: We aim to test whether leukocyte telomere length (LTL) is causally associated with the risk of bipolar disorder (BD) using the Mendelian randomization (MR) method. Methods: Results of a genome-wide association study (GWAS) conducted with 472,174 individuals of European descent were used to screen for single-nucleotide polymorphisms (SNPs) related with LTL traits. Summary-level data for BD (7,647 cases and 27,303 controls) were obtained from UK Biobank. An inverse-variance-weighted (IVW) method was employed as the primary MR analysis. Sensitivity analyses were conducted Results: Two-sample MR analysis revealed inverse relationships between genetically predicted LTL and BD risk (IVW OR [odds ratio] = 0.800, 95% CI [0.647-0.989] Conclusion: Our findings show that genetically determined LTL reduces the risk of BD. More research is required to clarify the mechanisms underlying this apparent causal connection. In addition, these findings may be useful for developing strategies for the prevention and treatment of BD.

Indexed as

Bipolar DisorderGenome-Wide Association StudyHumansLeukocytesMendelian Randomization AnalysisTelomereBipolar disorderGenome-wide association studyLeukocyte telomere lengthMendelian randomizationSingle-nucleotide polymorphismsSpinal stenosis

Identifiers

PMID37020849
PMCPMC10069421
OpenAlexW4362470884

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.