Evidence map›Paper›PMID 37020832›Full record

ReviewMatter2023

Self-driving laboratories: A paradigm shift in nanomedicine development.

Riley J Hickman, Pauric Bannigan, Zeqing Bao, Alán Aspuru-Guzik, Christine Allen

Abstract readReview
In one paragraph

Review in Matter, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

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  12. Design biology and mind-body health.Journal, genetic engineering & biotechnology · 2025
    Review
  13. MakingInternational journal of pharmaceutics: X · 2025
    Article
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  20. Machine learning in drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Riley J HickmanDepartment of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.
Pauric BanniganLeslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.
Zeqing BaoLeslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.
Alán Aspuru-GuzikDepartment of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.
Christine AllenLeslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanomedicines have transformed promising therapeutic agents into clinically approved medicines with optimal safety and efficacy profiles. This is exemplified by the mRNA vaccines against COVID-19, which were made possible by lipid nanoparticle technology. Despite the success of nanomedicines to date, their design remains far from trivial, in part due to the complexity associated with their preclinical development. Herein, we propose a nanomedicine materials acceleration platform (NanoMAP) to streamline the preclinical development of these formulations. NanoMAP combines high-throughput experimentation with state-of-the-art advances in artificial intelligence (including active learning and few-shot learning) as well as a web-based application for data sharing. The deployment of NanoMAP requires interdisciplinary collaboration between leading figures in drug delivery and artificial intelligence to enable this data-driven design approach. The proposed approach will not only expedite the development of next-generation nanomedicines but also encourage participation of the pharmaceutical science community in a large data curation initiative.

Indexed as

active learningautomationdrug deliveryhigh-throughput experimentationlipid-based nanoparticlesliposomesmachine learningmaterials acceleration platformsnanomedicinespolymer nanoparticlesself-driving laboratories

Identifiers

PMID37020832
PMCPMC9993483

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.