Evidence map›Paper›PMID 37020805›Full record

ArticleFrontiers in nutrition2023

Docosahexaenoic acid supplementation in gestational diabetes mellitus and neonatal metabolic health biomarkers.

Ya-Jie Xu, Wen-Juan Wang, Qiu-Yi Zhang, Meng-Nan Yang, Lin Zhang, Hua He, Yu Dong, Fengxiu Ouyang, Ying Gao, Jun Zhang and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03569501 (Influence of DHA/Oat on Maternal and Neonatal Metabolic Health in Gestational Diabetes Mellitus), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03569501 naunknown statusnot on this map

Influence of DHA/Oat on Maternal and Neonatal Metabolic Health in Gestational Diabetes Mellitus

TypeinterventionalSponsorXinhua Hospital, Shanghai Jiao Tong University School of MedicineRan2017 to 2019Enrolled80ConditionsGestational Diabetes Mellitus in PregnancyArmsDHA, oat grains
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Ya-Jie XuDepartment of Pediatrics, Xinhua Hospital, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Early Life Health Institute, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Wen-Juan WangDepartment of Pediatrics, Xinhua Hospital, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Early Life Health Institute, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Qiu-Yi ZhangCAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China.
Meng-Nan YangDepartment of Pediatrics, Xinhua Hospital, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Early Life Health Institute, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Lin ZhangDepartment of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Hua HeDepartment of Pediatrics, Xinhua Hospital, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Early Life Health Institute, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Yu DongDepartment of Pediatrics, Xinhua Hospital, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Early Life Health Institute, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Fengxiu OuyangDepartment of Pediatrics, Xinhua Hospital, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Early Life Health Institute, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Ying GaoCAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China.
Jun ZhangDepartment of Pediatrics, Xinhua Hospital, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Early Life Health Institute, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Tao ZhengDepartment Obstetrics and Gynecology, Xinhua Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Zhong-Cheng LuoDepartment of Pediatrics, Xinhua Hospital, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Early Life Health Institute, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Shanghai Jiao Tong University · CNShanghai Institute of Nutrition and Health · CNXinHua Hospital · CNInternational Peace Maternity & Child Health Hospital · CNUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objective: Gestational diabetes mellitus (GDM) "programs" an elevated risk of metabolic dysfunctional disorders in the offspring, and has been associated with elevated leptin and decreased adiponectin levels in cord blood. We sought to assess whether docosahexaenoic acid (DHA) supplementation in GDM affects neonatal metabolic health biomarkers especially leptin and adiponectin. Methods: In a randomized controlled trial, singleton pregnant women with Results: There were no significant differences in cord serum leptin, total and HMW adiponectin and IGF-1 concentrations between DHA supplementation and control groups (all Conclusion: Docosahexaenoic acid supplementation at 500  mg/day in GDM women did not affect neonatal metabolic biomarkers including leptin, adiponectin and IGF-1. The results are reassuring in light of the absence of influence on neonatal adipokines (leptin and adiponectin), and potential benefits to fetal growth and development. Clinical Trial Registration: Clinicaltrials.gov, NCT03569501.

Indexed as

adiponectincord bloodDHA (22:6ω–3)gestational diabetes mellitusleptinprenatal intervention

Identifiers

PMID37020805
PMCPMC10069675
OpenAlexW4327977273

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.