Evidence map›Paper›PMID 37020673›Full record

ReviewFrontiers in medicine2023

Effects of microRNAs on angiogenesis in diabetic wounds.

Bailey D Lyttle, Alyssa E Vaughn, James R Bardill, Anisha Apte, Lauren T Gallagher, Carlos Zgheib, Kenneth W Liechty

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. MicroRNA-409-3p/BTG2 signaling axis improves impaired angiogenesis and wound healing in obese mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  10. Review
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  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Bailey D LyttleLaboratory for Fetal and Regenerative Biology, Department of Surgery, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, United States.
Alyssa E VaughnLaboratory for Fetal and Regenerative Biology, Department of Surgery, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, United States.
James R BardillLaboratory for Fetal and Regenerative Biology, Department of Surgery, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, United States.
Anisha ApteLaboratory for Fetal and Regenerative Biology, Department of Surgery, College of Medicine, University of Arizona Health Sciences College of Medicine-Tucson, Tucson, AZ, United States.
Lauren T GallagherLaboratory for Fetal and Regenerative Biology, Department of Surgery, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, United States.
Carlos ZgheibLaboratory for Fetal and Regenerative Biology, Department of Surgery, College of Medicine, University of Arizona Health Sciences College of Medicine-Tucson, Tucson, AZ, United States.
Kenneth W LiechtyLaboratory for Fetal and Regenerative Biology, Department of Surgery, College of Medicine, University of Arizona Health Sciences College of Medicine-Tucson, Tucson, AZ, United States.
University of Arizona · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Colorado Denver · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus is a morbid condition affecting a growing number of the world population, and approximately one third of diabetic patients are afflicted with diabetic foot ulcers (DFU), which are chronic non-healing wounds that frequently progress to require amputation. The treatments currently used for DFU focus on reducing pressure on the wound, staving off infection, and maintaining a moist environment, but the impaired wound healing that occurs in diabetes is a constant obstacle that must be faced. Aberrant angiogenesis is a major contributor to poor wound healing in diabetes and surgical intervention is often necessary to establish peripheral blood flow necessary for healing wounds. Over recent years, microRNAs (miRNAs) have been implicated in the dysregulation of angiogenesis in multiple pathologies including diabetes. This review explores the pathways of angiogenesis that become dysregulated in diabetes, focusing on miRNAs that have been identified and the mechanisms by which they affect angiogenesis.

Indexed as

angiogenesischronic woundsdiabetes mellitusdiabetic foot ulcersmicroRNAwound healing

Identifiers

PMID37020673
PMCPMC10067680
OpenAlexW4327979079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.