Evidence map›Paper›PMID 37020572›Full record

ArticleCanadian journal of veterinary research = Revue canadienne de recherche veterinaire2023

Seneca Valley virus induces proinflammatory cytokine and chemokine response

Jianguo Dong, Mingrui Chen, Linyang Yu, Dan Rao, Ning Zhang, Feng Cong

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jianguo Dong *School of Animal Science and Veterinary Medicine, Xinyang Agriculture and Forestry University, Xinyang 464000, China (Dong, Chen, Rao); College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China (Yu); Laboratory Animals Monitoring Institute and Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou 510633, China (Cong); Henan Fengyuan Hepu Agriculture and Animal Husbandry, Zhumadian 463900, China (Zhang).
Mingrui ChenSchool of Animal Science and Veterinary Medicine, Xinyang Agriculture and Forestry University, Xinyang 464000, China (Dong, Chen, Rao); College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China (Yu); Laboratory Animals Monitoring Institute and Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou 510633, China (Cong); Henan Fengyuan Hepu Agriculture and Animal Husbandry, Zhumadian 463900, China (Zhang).
Linyang YuSchool of Animal Science and Veterinary Medicine, Xinyang Agriculture and Forestry University, Xinyang 464000, China (Dong, Chen, Rao); College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China (Yu); Laboratory Animals Monitoring Institute and Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou 510633, China (Cong); Henan Fengyuan Hepu Agriculture and Animal Husbandry, Zhumadian 463900, China (Zhang).
Dan Rao *School of Animal Science and Veterinary Medicine, Xinyang Agriculture and Forestry University, Xinyang 464000, China (Dong, Chen, Rao); College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China (Yu); Laboratory Animals Monitoring Institute and Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou 510633, China (Cong); Henan Fengyuan Hepu Agriculture and Animal Husbandry, Zhumadian 463900, China (Zhang).
Ning ZhangSchool of Animal Science and Veterinary Medicine, Xinyang Agriculture and Forestry University, Xinyang 464000, China (Dong, Chen, Rao); College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China (Yu); Laboratory Animals Monitoring Institute and Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou 510633, China (Cong); Henan Fengyuan Hepu Agriculture and Animal Husbandry, Zhumadian 463900, China (Zhang).
Feng CongSchool of Animal Science and Veterinary Medicine, Xinyang Agriculture and Forestry University, Xinyang 464000, China (Dong, Chen, Rao); College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China (Yu); Laboratory Animals Monitoring Institute and Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou 510633, China (Cong); Henan Fengyuan Hepu Agriculture and Animal Husbandry, Zhumadian 463900, China (Zhang).
Xinyang College of Agriculture and Forestry · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Seneca Valley virus (SVV) is an oncolytic virus, which belongs to the Picornaviridae family, that causes blisters on the nose and hooves, affecting the production performance of pigs. However, the function of proinflammatory cytokines and chemokines in SVV infection is still unclear. In our study, SVV infection could induce a high expression of proinflammatory cytokines interleukin (IL)-1α, IL-1β, and tumor necrosis factor α (TNF-α) and chemokines, including chemokine (C-C motif) ligand 2 (CCL2), chemokine (C-C motif) ligand 5 (CCL5), and chemokine (C-X-C motif) ligand 10 (CXCL10). Interfered genes of IL-1α, IL-1β, and TNF-α inhibited virus replication, but interfered genes of CCL2, CCL5, and CXCL10 promoted virus replication. These results indicate that proinflammatory cytokines and chemokines are involved in SVV infection; this will be beneficial to explore the pathogenesis and cytokine therapy of SVV.

Indexed as

CytokinesPicornaviridaeAnimalsChemokinesSwineTumor Necrosis Factor-alphaChemokinesCytokinesTumor Necrosis Factor-alpha

Identifiers

PMID37020572
PMCPMC10069161
OpenAlexW4362657872

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.