ArticleNeurobiology of sleep and circadian rhythms2023
Ontogenesis of the molecular response to sleep loss.
Article in Neurobiology of sleep and circadian rhythms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Shank3 mutation disrupts the molecular signature of sleepiness across development.bioRxiv : the preprint server for biology · 2026Article
- Latent mechanisms of plasticity are upregulated during sleep.Current opinion in neurobiology · 2025Review
- Transcriptional dynamics of sleep deprivation and subsequent recovery sleep in the male mouse cortex.Physiological genomics · 2025Article
- Revisiting brain gene expression changes and protein modifications tracking homeostatic sleep pressure.Npj biological timing and sleep · 2025Review
- Developing forebrain synapses are uniquely vulnerable to sleep loss.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A global transcriptional atlas of the effect of acute sleep deprivation in the mouse frontal cortex.iScience · 2024Article
- Investigation of Common Pathways and Putative Biomarker Candidates of Colorectal Cancer and Insomnia by Using IntegrativeIranian journal of biotechnology · 2024Article
- Human serum proteomics reveals a molecular signature after one night of sleep deprivation.Sleep advances : a journal of the Sleep Research Society · 2024Article
- A Global Transcriptional Atlas of the Effect of Sleep Deprivation in the Mouse Frontal Cortex.bioRxiv : the preprint server for biology · 2023Article
- A conserved role forSleep advances : a journal of the Sleep Research Society · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Sleep deprivation (SD) results in profound cellular and molecular changes in the adult mammalian brain. Some of these changes may result in, or aggravate, brain disease. However, little is known about how SD impacts gene expression in developing animals. We examined the transcriptional response in the prefrontal cortex (PFC) to SD across postnatal development in male mice. We used RNA sequencing to identify functional gene categories that were specifically impacted by SD. We find that SD has dramatically different effects on PFC genes depending on developmental age. Gene expression differences after SD fall into 3 categories: present at all ages (conserved), present when mature sleep homeostasis is first emerging, and those unique to certain ages. Developmentally conserved gene expression was limited to a few functional categories, including Wnt-signaling which suggests that this pathway is a core mechanism regulated by sleep. In younger ages, genes primarily related to growth and development are affected while changes in genes related to metabolism are specific to the effect of SD in adults.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.