Evidence map›Paper›PMID 37020301›Full record

ArticleJournal of nanobiotechnology2023

Hydrogel armed with Bmp2 mRNA-enriched exosomes enhances bone regeneration.

Zhujun Yang, Xuejian Li, Xueqi Gan, Mengying Wei, Chunbao Wang, Guodong Yang, Yimin Zhao, Zhuoli Zhu, Zhongshan Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 2 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.

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  4. Extracellular Vesicles and Their Role in Osteogenesis.Bioengineering (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Zhujun Yang *Department of Stomatology, Xi'an Central Hospital Affiliated to Xi'an Jiaotong University, Xi'an, 710003, Shaanxi, China.
Xuejian Li *State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China.
Xueqi Gan *State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Sichuan, 610041, Chengdu, China.
Mengying WeiThe State Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.
Chunbao WangCollege of Chemistry and Bio-Engineering, Yichun University, Yichun, 336000, Jiangxi, China.
Guodong YangThe State Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.
Yimin ZhaoState Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China. zhaoymdentist@163.com.
Zhuoli ZhuState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Sichuan, 610041, Chengdu, China. zzl7507@126.com.
Zhongshan WangState Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China. wzs_fmmu@163.com.
Air Force Medical University · CNSichuan University · CNXian Central Hospital · CNYichun University · CN

Funding

National Natural Science Foundation of China 81700930Shaanxi Science and Technology Research and Development Project 2021SF-105Sichuan Science and Technology Program 2020YJ0297
6 · The paper itself

Abstract

backgroundSustained release of bioactive BMP2 (bone morphogenetic protein-2) is important for bone regeneration, while the intrinsic short half-life of BMP2 at protein level cannot meet the clinical need. In this study, we aimed to design Bmp2 mRNA-enriched engineered exosomes, which were then loaded into specific hydrogel to achieve sustained release for more efficient and safe bone regeneration.

resultsBmp2 mRNA was enriched into exosomes by selective inhibition of translation in donor cells, in which NoBody (non-annotated P-body dissociating polypeptide, a protein that inhibits mRNA translation) and modified engineered BMP2 plasmids were co-transfected. The derived exosomes were named Exo

conclusionsTogether, the proposed Exo

Indexed as

ExosomesHydrogelsBone Morphogenetic Protein 2Bone RegenerationDelayed-Action PreparationsOsteogenesisRNA, MessengerBone Morphogenetic Protein 2Delayed-Action PreparationsHydrogelsRNA, MessengerBmp2 mRNACP05Engineered exosomeGene therapyHydrogelOsteogenesis

Identifiers

PMID37020301
PMCPMC10075167
OpenAlexW4362634152

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.