Evidence map›Paper›PMID 37020279›Full record

SynthesisBMC cancer2023

Risk factors for cancer of unknown primary: a literature review.

Karlijn E P E Hermans, Fatemeh Kazemzadeh, Caroline Loef, Rob L H Jansen, Iris D Nagtegaal, Piet A van den Brandt, Leo J Schouten

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in BMC cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Epidemiologic, histopathological, and prognostic analysis of cancer of unknown primary in an Iranian population.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025
    Article
  7. Cyclic Lipopeptides as Selective Anticancer Agents:Anti-cancer agents in medicinal chemistry · 2025
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Karlijn E P E HermansDepartment of Epidemiology, GROW School for Oncology and Reproduction, Maastricht University, PO Box 616, 6200 MD, Maastricht, the Netherlands. karlijn.hermans@maastrichtuniversity.nl.ORCID http://orcid.org/0000-0002-7629-0820
Fatemeh KazemzadehDepartment of Pathology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Caroline LoefDepartment of Research, Comprehensive Cancer Organization the Netherlands, Utrecht, the Netherlands.
Rob L H JansenDepartment of Research, Comprehensive Cancer Organization the Netherlands, Utrecht, the Netherlands.
Iris D NagtegaalDepartment of Pathology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Piet A van den BrandtDepartment of Epidemiology, GROW School for Oncology and Reproduction, Maastricht University, PO Box 616, 6200 MD, Maastricht, the Netherlands.
Leo J SchoutenDepartment of Epidemiology, GROW School for Oncology and Reproduction, Maastricht University, PO Box 616, 6200 MD, Maastricht, the Netherlands.
Maastricht University · NLNetherlands Comprehensive Cancer Organisation · NLRadboud University Nijmegen · NL

Funding

Wereld Kanker Onderzoek Fonds 2017/1628
6 · The paper itself

Abstract

Cancer of Unknown Primary (CUP) is metastatic cancer with an unidentifiable primary tumour origin during life. It remains difficult to study the occurrence and aetiology of CUP. Hitherto, it is unclear whether risk factors are associated with CUP, yet identifying these factors could reveal whether CUP is a specific entity or a cluster of metastasised cancers from various primary tumour origins. Epidemiological studies on possible CUP risk factors were systematically searched in PubMed and Web of Science on February 1

Indexed as

Diabetes MellitusNeoplasms, Unknown PrimaryAlcohol DrinkingHumansRisk FactorsSmokingCancer of unknown primaryReviewRisk factors

Identifiers

PMID37020279
PMCPMC10077635
OpenAlexW4362636222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.