Evidence map›Paper›PMID 37020275›Full record

Trial reportBMC neuroscience2023

Anodal tDCS over the left DLPFC but not M1 increases muscle activity and improves psychophysiological responses, cognitive function, and endurance performance in normobaric hypoxia: a randomized controlled trial.

Matin Etemadi, Ehsan Amiri, Vahid Tadibi, Sidney Grospretre, Vahid Valipour Dehnou, Daniel Gomes da Silva Machado

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

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  5. Modulating Brain Activity to Improve Goal-directed Physical Activity in Older Adults: A Pilot Randomized Controlled Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
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  11. Effects ofFood science & nutrition · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Matin EtemadiExercise Metabolism and Performance Lab (EMPL), Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran.
Ehsan AmiriExercise Metabolism and Performance Lab (EMPL), Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran. e.amiri@razi.ac.ir.ORCID 0000-0001-6120-9252
Vahid TadibiExercise Metabolism and Performance Lab (EMPL), Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran.
Sidney GrospretreEA4660-C3S Laboratory-Culture, Sports, Health and Society, University Bourgogne France-Comte, Besancon, France.ORCID 0000-0003-1023-5842
Vahid Valipour DehnouDepartment of Sports Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khorramabad, Iran.
Daniel Gomes da Silva MachadoResearch Group in Neuroscience of Human Movement (NeuroMove), Department of Physical Education, Federal University of Rio Grande Do Norte, Natal, RN, Brazil.ORCID 0000-0002-8426-0488
Razi University · IRLorestan University · IRUniversidade Federal do Rio Grande do Norte · BRUniversité Bourgogne Franche-Comté · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranscranial direct current stimulation (tDCS) has been shown to have positive effects on exercise performance and cognitive function in the normal ambient condition. Hypoxia is deemed a stressful situation with detrimental effects on physiological, psychological, cognitive, and perceptual responses of the body. Nevertheless, no study has evaluated the efficacy of tDCS for counteracting the negative effects of hypoxic conditions on exercise performance and cognition so far. Hence, in the present study, we investigated the effects of anodal tDCS on endurance performance, cognitive function, and perceptual responses in hypoxia. PARTICIPANTS AND

methodsFourteen endurance-trained males participated in five experimental sessions. After familiarization and measuring peak power output in hypoxia, in the first and second sessions, through the 3rd to 5th sessions, participants performed a cycling endurance task until exhaustion after 30 min hypoxic exposure at resting position followed by 20 min of anodal stimulation of the motor cortex (M1), left dorsolateral prefrontal cortex (DLPFC), or sham-tDCS. Color-word Stroop test and choice reaction time were measured at baseline and after exhaustion. Time to exhaustion, heart rate, saturated O

resultsThe results showed a longer time to exhaustion (+ 30.96%, p

conclusionsWe concluded that, as a novel finding, anodal stimulation of the left DLPFC might provide an ergogenic aid for endurance performance and cognitive function under the hypoxic condition probably via increasing neural drive to the working muscles, lowering RPE, and increasing perceptual responses.

Indexed as

Transcranial Direct Current StimulationCognitionDorsolateral Prefrontal CortexHumansMaleMusclesPrefrontal CortexCircumplex model of affectElectromyographyNon-invasive brain stimulationPerceived exertionPerceptual responsesTime to exhaustion

Identifiers

PMID37020275
PMCPMC10077713
OpenAlexW4362604003

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.