ArticleBMC ophthalmology2023
Aqueous humor cytokine levels are associated with the severity of visual field defects in patients with primary open-angle glaucoma.
Article in BMC ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Cytokines in patients with Posner-Schlossman syndrome.Frontiers in immunology · 2026Article
- Microtopography screening to modulate the mitogenic effects of aqueous humor on human tenon fibroblasts.Frontiers in bioengineering and biotechnology · 2026Article
- Pro-Inflammatory Cytokines in Aqueous Humor From ADAMTS10-Mutant Beagles at an Early Stage of Open-Angle Glaucoma.Veterinary ophthalmology · 2026Article
- Intravitreal injection of SARM1 siRNA in TNF-induced optic nerve degeneration.International ophthalmology · 2025Article
- Antioxidant Support for the Corneal Endothelium: Evidence from Vitamin C Supplementation in Hard Cataract Phacoemulsification.F1000Research · 2025Article
- Aqueous humor cytokines levels and illuminated microcatheter-assisted circumferential trabeculotomy outcome in open-angle glaucoma patients: a 24-month prospective study.Frontiers in immunology · 2025Article
- Pro-inflammatory S100A9 contributes to retinal ganglion cell degeneration in glaucoma.Frontiers in immunology · 2025Article
- Suggestive evidence of male specific genetic association of IL8 -251T>A promoter polymorphism with primary angle closure glaucoma in a north Indian Punjabi population.BMC ophthalmology · 2024Article
- Translational Research and Therapies for Neuroprotection and Regeneration of the Optic Nerve and Retina: A Narrative Review.International journal of molecular sciences · 2024Review
- Parallel Analysis of Exosomes and Cytokines in Aqueous Humor Samples to Evaluate Biomarkers for Glaucoma.Cells · 2024Article
- Inflammation and Neurodegeneration in Glaucoma: Isolated Eye Disease or a Part of a Systemic Disorder? - Serum Proteomic Analysis.Journal of inflammation research · 2024Article
- Expression of IL-4 and IL-12 in the aqueous humor of patients with chronic primary angle-closure glaucoma.Frontiers in medicine · 2024Article
- Aqueous Humor Cytokine Profile in Primary Congenital Glaucoma.Journal of clinical medicine · 2023Article
- Primary Open Angle Glaucoma Diagnosis Using Pattern Electroretinogram Parameters.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Sestrin 2 protects human lens epithelial cells from oxidative stress and apoptosis induced by hydrogen peroxide by regulating the mTOR/Nrf2 pathway.International journal of immunopathology and pharmacologyArticle
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundTo evaluate the aqueous humor (AH) levels of cytokines in primary open-angle glaucoma (POAG) patients and cataract patients.
methodsThirty-eight POAG patients and 26 cataract patients were recruited. Peripheral blood (PB) was collected from each subject. The POAG group was divided into 2 subgroups according to the severity of visual field defects. The cutoff point of the mean deviation (MD) of the visual field was -12 dB. AH was obtained at the time of anterior chamber puncture during cataract or glaucoma surgery by using a 27-gauge needle attached to a microsyringe. AH and PB levels of interleukin-2 (IL-2), tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta2 (TGF-β2) and IL-4 were assayed by enzyme-linked immunosorbent assay. Postoperative intraocular pressures (IOPs) of POAG patients were recorded during the follow-up period.
resultsTNF-α and TGF-β2 showed significantly higher AH levels in the POAG group than in the cataract group (P < 0.001 and P = 0.001, respectively). For the POAG group, preoperative IOPs were significantly positively correlated with AH levels of TNF-α (r
conclusionThe levels of TNF-α and TGF-β2 showed different profiles in POAG patients and cataract patients. AH levels of TGF-β2 were correlated with the severity of glaucomatous neuropathy in POAG patients. The findings suggest possible roles for cytokines in the pathogenesis and development of POAG.
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