ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2023
The incomplete circle of Willis is associated with vulnerable intracranial plaque features and acute ischemic stroke.
Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Systemic inflammatory factors combined with HR-VWI-based plaque vulnerability discriminate ischemic phenotypes and predict prognosis in patients with intracranial atherosclerosis.Insights into imaging · 2026Article
- Circle of Willis Variants and Their Association with Outcome after Successful Revascularization of Anterior Large Vessel Occlusion.AJNR. American journal of neuroradiology · 2025Article
- Infarction in bilateral corona radiata presented as unilateral peripheral facial paralysis: a case report.BMC neurology · 2025Article
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundThe circle of Willis (CoW) plays a significant role in intracranial atherosclerosis (ICAS). This study investigated the relationship between different types of CoW, atherosclerosis plaque features, and acute ischemic stroke (AIS).
methodsWe investigated 97 participants with AIS or transient ischemic attacks (TIA) underwent pre- and post-contrast 3T vessel wall cardiovascular magnetic resonance within 7 days of the onset of symptoms. The culprit plaque characteristics (including enhancement grade, enhancement ratio, high signal in T
resultPatients with incomplete A-CoW showed a higher plaque enhancement ratio (P = 0.002), enhancement grade (P = 0.01), and normalized wall index (NWI) (P = 0.018) compared with the patients with complete A-CoW. A higher proportion of patients with incomplete symptomatic P-CoW demonstrated more culprit plaques with high T
conclusionsThis study demonstrated that incomplete A-CoW was associated with enhancement grade of the culprit plaque, and incomplete symptomatic side P-CoW was associated with the presence of HT
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