ArticleBMC musculoskeletal disorders2023
Diabetes mellitus is a potential risk factor for aseptic loosening around hip and knee arthroplasty.
Article in BMC musculoskeletal disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Short to mid-term outcomes of hip arthroscopy for femoroacetabular impingement and labral tears in patients with diabetes.Journal of hip preservation surgery · 2026Article
- Foot and ankle biomaterials: a comprehensive review of current applications, challenges, and future directions.Journal of orthopaedic translation · 2026Review
- Anti-diabetic medications' effect on outcomes and glycemic markers following TJA in patients with type 2 diabetes.Archives of orthopaedic and trauma surgery · 2025Article
- Causative factors for varus tibial baseplate subsidence in primary total knee arthroplasty: A retrospective analysis.Journal of orthopaedics · 2025Article
- Article
- Polymorphisms in rs2069845 are associated with IL-6 and soluble IL-6 receptor levels during total joint replacement.PloS one · 2025Article
- Genetic and Modifiable Risk Factors for Postoperative Complications of Total Joint Arthroplasty: A Genome-Wide Association and Mendelian Randomization Study.Bioengineering (Basel, Switzerland) · 2024Article
- Comprehensive evaluation of risk factors for aseptic loosening in cemented total knee arthroplasty: A systematic review and meta-analysis.Journal of experimental orthopaedics · 2024Review
- Letter to the editor regarding the article: "Dyslipidaemia is associated with Cutibacterium acnes hip and knee prosthetic joint infection".International orthopaedics · 2024Article
- Preoperative Oral Health Screening in Patients Undergoing Hip and Knee Arthroplasty: A Cross-Sectional Study.Current health sciences journalArticle
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAseptic loosening is a leading cause of revision following total hip and knee arthroplasty which is caused by chronic inflammation around the prosthesis. Diabetes mellitus causes systemic inflammatory changes which could increase the risk of aseptic loosening. This study investigated the association between diabetes mellitus and aseptic loosening around hip and knee arthroplasty.
methodsA case-control study was conducted at a single arthroplasty centre over the seven-year period of January 2015 to December 2021. Cases were defined as any adult patient undergoing revision hip or knee arthroplasty for aseptic loosening. Controls were randomly selected patients undergoing primary total hip or knee arthroplasty during the same period at a 1:4 ratio. Risk factors were compared between the two groups.
resultsA total of 440 patients were included in our study - 88 in the aseptic loosening group and 352 patients in the control group. The odds of having diabetes mellitus in the aseptic loosening group was 2.78 (95%CI 1.31-5.92, P = 0.01). Other risk factors were not significantly different between the two groups.
conclusionsThe incidence of diabetes mellitus is significantly greater in patients undergoing revision arthroplasty for aseptic loosening. Further research is required to explore whether this association is indeed causative.
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