SynthesisBMC musculoskeletal disorders2023
Vancomycin presoak reduces infection in anterior cruciate ligament reconstruction: a systematic review and meta-analysis.
Synthesis in BMC musculoskeletal disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06166381 (Parenteral Versus Combined Parenteral With Vancomycin-soaked Graft in Decreasing the Risk of Infection in ACL Reconstruction Surgery), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Parenteral Versus Combined Parenteral With Vancomycin-soaked Graft in Decreasing the Risk of Infection in ACL Reconstruction Surgery: A Randomized Controlled Trial
Who cites it
12 citing papers in PubMed, 12 citations in OpenAlex.
- Assessing the Outcomes of Anterior Cruciate Ligament Reconstruction with or without the use of Antibiotic Solution in Graft Preparation: A Randomized Control Trial.Annals of African medicine · 2026Trial
- In vitro evaluation of vancomycin-loaded Marlex mesh against staphylococci isolated from periprosthetic joint infection.Bone & joint research · 2026Article
- Pretreatment With Vancomycin Prevents Staphylococcal Biofilm Formation on Marlex Mesh.Arthroplasty today · 2026Article
- Infection Following ACL Reconstruction: From Prevention to Treatment.The archives of bone and joint surgery · 2026Review
- Semitendinosus vs quadriceps tendon autograft in anterior cruciate ligament reconstruction (SEQUAR): protocol for a prospective randomized controlled trial.BMC musculoskeletal disorders · 2025Article
- The Role of Intrawound Vancomycin Powder in Reducing Surgical Site Infections in Orthopedic Surgery: A Comprehensive Narrative Review of Its Efficacy, Safety, and Applications.Indian journal of orthopaedics · 2025Review
- Septic Arthritis After Anterior Cruciate Ligament Reconstruction: A Comparative Study of Pediatric, Adolescent, and Young Adult Populations.Orthopaedic journal of sports medicine · 2025Article
- Prevention and Management of Postoperative Infection After Anterior Cruciate Ligament Reconstruction: A Narrative Review.Journal of clinical medicine · 2025Review
- Assessing Residual Moisture After Sterilization as an Overlooked Source of Intraoperative Bacterial Contamination in Knee Intra-articular Reconstructions: Evaluating the Reliability of Routine Procedures and Tests.Orthopaedic journal of sports medicine · 2025Article
- Infection after Anterior Cruciate Ligament Reconstruction: A Narrative Review of the Literature.Healthcare (Basel, Switzerland) · 2024Review
- Semitendinosus tendons are commonly contaminated with skin flora during graft harvest for anterior cruciate ligament reconstruction.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- Wrap It! Preventive Antimicrobial Treatment Shows No Negative Effects on Tenocytes and Tendons-A Comprehensive Approach.Journal of clinical medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare the effect of vancomycin presoak treatment of grafts during anterior cruciate ligament reconstruction on the incidence of postoperative infection or septic arthritis.
methodsStudies published before May 3, 2022 investigating vancomycin presoak of grafts during anterior cruciate ligament reconstruction were searched in the PubMed and Cochrane Central Register of Controlled Trials. Studies were screened, and data on the incidence of postoperative infection or septic arthritis were extracted and included in the analysis.
resultsThirteen studies were included for analysis after search screening, yielding a total of 31,150 participants for analysis, of whom 11,437 received graft vancomycin presoak treatment, and 19,713 did not receive treatment. Participants who received vancomycin treatment had significantly lower infection rates (0.09% versus 0.74%; OR 0.17; 95% CI 0.10, 0.30; P < 0.00001).
conclusionPre-soaking of the graft with vancomycin during ACL reconstruction reduced the incidence of postoperative infection and septic arthritis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.