ArticleBMC psychiatry2023
Amygdala signal abnormality and cognitive impairment in drug-naïve schizophrenia.
Article in BMC psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Magnetic Seizure Therapy vs Electroconvulsive Therapy in Schizophrenia: Prefrontal-Amygdala Plasticity and Cognitive Safety.Neuropsychiatric disease and treatment · 2025Trial
- Simultaneous PET/fMRI distinguishes the separate and synergistic effects of T2DM and MCI on cerebral glucose metabolism and fALFF.Scientific reports · 2026Article
- Altered Functional Connectivity of Amygdala Subregions with Large-Scale Brain Networks in Schizophrenia: A Resting-State fMRI Study.Tomography (Ann Arbor, Mich.) · 2025Article
- Left amygdala alterations mediate the effects of negative symptoms on social dysfunction in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Brain metabolic profiling of schizophrenia: a path towards a better understanding of the neuropathogenesis of psychosis.Metabolic brain disease · 2024Review
- Differences in fractional amplitude of low-frequency fluctuations (fALFF) and cognitive function between untreated major depressive disorder and schizophrenia with depressive mood patients.BMC psychiatry · 2024Article
- Selective disrupted gray matter volume covariance of amygdala subregions in schizophrenia.Frontiers in psychiatry · 2024Article
- Abnormalities of the Amygdala in schizophrenia: a real world study.BMC psychiatry · 2023Article
- Distinguishing functional and structural MRI abnormalities between bipolar and unipolar depression.Frontiers in psychiatry · 2023Article
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Authors and funding
14 authors.
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Abstract
backgroundRecently studies had showed that the amygdala may take part in the cognitive impairment in schizophrenia (SC). However, the mechanism is still unclear, so we explored the relationship between the amygdala resting state magnetic resonance imaging (rsMRI) signal and cognitive function, to provide a reference for the follow-up study.
methodsWe collected 59 drug-naïve SCs and 46 healthy controls (HCs) from the Third People's Hospital of Foshan. The rsMRI technique and automatic segmentation tool were used to extract the volume and functional indicators of the SC's amygdala. The Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of the disease, and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was used to assess cognitive function. Pearson correlation analysis was used to compare the relationship between the structural and functional indicators of the amygdala and PANSS and RBANS.
results(1) There was no significant difference between SC and HC in age, gender and years of education. Compared with HC, the PANSS score of SC increased and the RBANS score decreased significantly. Meanwhile, the left amygdala volume decreased (t=-3.675, p < 0.001), and the Fractional amplitude of low-frequency fluctuations (FALFF) values of bilateral amygdala increased (t
conclusionThe abnormal volume and function of the amygdala play important roles in the disease process of SC, and are closely related to cognitive impairment.
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