ArticleNature neuroscience2023
Differential replay of reward and punishment paths predicts approach and avoidance.
Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Article
- Episodic memory facilitates flexible decision-making via access to detailed events.Nature human behaviour · 2026Article
- Reasoning with programs in replay.bioRxiv : the preprint server for biology · 2025Article
- Trait anxiety is associated with reduced reward-related replay at rest.Nature communications · 2025Article
- Article
- Subregions in the ventromedial prefrontal cortex integrate threat and protective information to meta-represent safety.PLoS biology · 2025Article
- Context changes retrieval of prospective outcomes during decision deliberation.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Memory reactivation generates new, adaptive behaviours that reach beyond direct experience.Scientific reports · 2024Article
- How Distributed Subcortical Integration of Reward and Threat May Inform Subsequent Approach-Avoidance Decisions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Replay-triggered brain-wide activation in humans.Nature communications · 2024Article
- Reactivation strength during cued recall is modulated by graph distance within cognitive maps.eLife · 2024Article
- Heuristics in risky decision-making relate to preferential representation of information.Nature communications · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Neural replay is implicated in planning, where states relevant to a task goal are rapidly reactivated in sequence. It remains unclear whether, during planning, replay relates to an actual prospective choice. Here, using magnetoencephalography (MEG), we studied replay in human participants while they planned to either approach or avoid an uncertain environment containing paths leading to reward or punishment. We find evidence for forward sequential replay during planning, with rapid state-to-state transitions from 20 to 90 ms. Replay of rewarding paths was boosted, relative to aversive paths, before a decision to avoid and attenuated before a decision to approach. A trial-by-trial bias toward replaying prospective punishing paths predicted irrational decisions to approach riskier environments, an effect more pronounced in participants with higher trait anxiety. The findings indicate a coupling of replay with planned behavior, where replay prioritizes an online representation of a worst-case scenario for approaching or avoiding.
Indexed as
Identifiers
37020116What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.