Evidence map›Paper›PMID 37020024›Full record

ArticleNature2023

mRNA decoding in human is kinetically and structurally distinct from bacteria.

Mikael Holm, S Kundhavai Natchiar, Emily J Rundlet, Alexander G Myasnikov, Zoe L Watson, Roger B Altman, Hao-Yuan Wang, Jack Taunton, Scott C Blanchard

Open access · hybridAbstract readComparative Study
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 102 citations in OpenAlex.

  1. Article
  2. RNAViruses · 2026
    Review
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  4. Article
  5. Article
  6. Review
  7. RiboScreenBiomedicines · 2026
    Review
  8. Article
  9. Article
  10. The molecular architecture of tunneling nanotubes.bioRxiv : the preprint server for biology · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. The regulation, function and disease relevance of cytoplasmic tRNAs.Nature reviews. Molecular cell biology · 2026
    Review
  15. Article
  16. Review
  17. Article
  18. NNature · 2026
    Article
  19. Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Mikael Holm *Department of Structural Biology, St Jude Children's Research Hospital, Memphis, TN, USA.
S Kundhavai Natchiar *Department of Structural Biology, St Jude Children's Research Hospital, Memphis, TN, USA.
Emily J Rundlet *Department of Structural Biology, St Jude Children's Research Hospital, Memphis, TN, USA.
Alexander G MyasnikovDepartment of Structural Biology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-2607-7121
Zoe L WatsonDepartment of Structural Biology, St Jude Children's Research Hospital, Memphis, TN, USA.
Roger B AltmanDepartment of Structural Biology, St Jude Children's Research Hospital, Memphis, TN, USA.
Hao-Yuan WangDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8490-8793
Jack TauntonDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-9627-5898
Scott C BlanchardDepartment of Structural Biology, St Jude Children's Research Hospital, Memphis, TN, USA. Scott.Blanchard@StJude.org.ORCID http://orcid.org/0000-0003-2717-9365
St. Jude Children's Research Hospital · USUniversity of California, San Francisco · USQB3 · US

Funding

Center for Multi-Scale Analysis of the Human EpitranscriptomeRM1HG011563 · NHGRI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SAMIE R JAFFREY, Kathryn D Meyer · 2021 to 2026
$22.2M
Imaging Protein Synthesis on the Ribosome using Single-Molecule FRETR01GM079238 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BLANCHARD, SCOTT C · 2006 to 2023
$7.0M
Tri-Institutional PhD Program in Chemical BiologyT32GM115327 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI TAN, DEREK S · 2015 to 2019
$741k
NHGRI NIH HHS RM1 HG011563NIGMS NIH HHS R01 GM079238NIGMS NIH HHS T32 GM115327
6 · The paper itself

Abstract

In all species, ribosomes synthesize proteins by faithfully decoding messenger RNA (mRNA) nucleotide sequences using aminoacyl-tRNA substrates. Current knowledge of the decoding mechanism derives principally from studies on bacterial systems

Indexed as

BacteriaProtein BiosynthesisCryoelectron MicroscopyHumansPeptide Elongation Factor 1RibosomesRNA, MessengerRNA, Transfer, Amino AcylSingle Molecule ImagingEEF1A1 protein, humanPeptide Elongation Factor 1RNA, MessengerRNA, Transfer, Amino Acyl

Identifiers

PMID37020024
PMCPMC10156603
OpenAlexW4362606436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.