Evidence map›Paper›PMID 37020023›Full record

ArticleNature2023

De novo design of modular peptide-binding proteins by superhelical matching.

Kejia Wu, Hua Bai, Ya-Ting Chang, Rachel Redler, Kerrie E McNally, William Sheffler, T J Brunette, Derrick R Hicks, Tomos E Morgan, Tim J Stevens and 11 more

Abstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Tuning Polyacrylate Composition to Recognize and Modulate Fluorescent Proteins.Angewandte Chemie (International ed. in English) · 2026
    Article
  8. Article
  9. bioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Nucleation limited assembly and polarized growth of abioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. bioRxiv : the preprint server for biology · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Kejia Wu *Department of Biochemistry, University of Washington, Seattle, WA, USA.
Hua Bai *Department of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-0448-4052
Ya-Ting ChangDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-2580-4622
Rachel RedlerDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA.
Kerrie E McNallyMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0000-0003-2376-3003
William ShefflerDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
T J BrunetteDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-0748-8224
Derrick R HicksDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2950-1848
Tomos E MorganMRC Laboratory of Molecular Biology, Cambridge, UK.
Tim J StevensMRC Laboratory of Molecular Biology, Cambridge, UK.
Adam BroermanDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-6878-1769
Inna GoreshnikDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Michelle DeWittDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Cameron M ChowDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Yihang ShenDepartment of Computational Biology, Carnegie Mellon University, Pittsburgh, PA, USA.
Lance StewartDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-4264-5125
Emmanuel DeriveryMRC Laboratory of Molecular Biology, Cambridge, UK. derivery@mrc-lmb.cam.ac.uk.ORCID http://orcid.org/0000-0003-3927-5944
Daniel Adriano SilvaDepartment of Biochemistry, University of Washington, Seattle, WA, USA. dadriano@gmail.com.ORCID http://orcid.org/0000-0002-3195-9009
Gira BhabhaDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-0624-6178
Damian C EkiertDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-2570-0404
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.ORCID http://orcid.org/0000-0001-7896-6217

Funding

Project 4: Novel reagent development to enable molecular characterizationU19AG065156 · NIA · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID · 2020 to 2024
$15.9M
Unravelling lipid trafficking for the bacterial outer membraneR35GM128777 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Damian Ekiert · 2018 to 2026
$4.1M
Medical Research Council MC_UP_1201/13NIA NIH HHS 5U19AG065156-02NIA NIH HHS U19 AG065156NIGMS NIH HHS R35 GM128777Wellcome Trust 220480
6 · The paper itself

Abstract

General approaches for designing sequence-specific peptide-binding proteins would have wide utility in proteomics and synthetic biology. However, designing peptide-binding proteins is challenging, as most peptides do not have defined structures in isolation, and hydrogen bonds must be made to the buried polar groups in the peptide backbone

Indexed as

PeptidesProtein EngineeringProteinsAmino Acid SequenceHydrogen BondingModels, MolecularProtein BindingProtein ConformationProtein FoldingPeptidesProteins

Identifiers

PMID37020023
PMCPMC10115654

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.