ArticleNature2023
Lung adenocarcinoma promotion by air pollutants.
Registry-linked trialOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07383454 (Lung Cancer Screening in Population Who Had Never Smoked and the Validation of Lung Cancer Risk Prediction Model), which is not on this map. Cited by 397 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
397citing papers in PubMed, 1 pooled it
107.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lung Cancer Screening in Population Who Had Never Smoked and the Validation of Lung Cancer Risk Prediction Model
Who cites it
397 citing papers in PubMed, 1 synthesis or guideline pooled it, 683 citations in OpenAlex.
- Environmental Noise Exposure and Risk of Cancer: A Systematic Review and Meta-Analysis.Current environmental health reports · 2025Pooled it
- Breathing in harm: current insights into the effects of air pollution on cardiorespiratory health.Medical gas research · 2027Review
- The double face of IL-1β in lung cancer.Oncoimmunology · 2026Article
- Cadmium inhibits hSMUG1-mediated uracil excision: quantitative analysis and mitigation byJournal of enzyme inhibition and medicinal chemistry · 2026Article
- Long-term ambient benzene exposure increases incident NAFLD risk through accelerated biological aging.iScience · 2026Article
- High-Throughput Geocoding to Assess Short-Term Air Pollution in Correlation With Mortality in a French Cancer Patient Cohort.International journal of cancer · 2026Article
- Lung Cancer Patients Display Increased Expression of Bovine Meat and Milk Factor (BMMF) Proteins in Peritumor Alveolar Macrophages.International journal of cancer · 2026Article
- Fc-Dependent Targeting of the GAS6-MERTK Axis With Monoclonal and Bispecific Antibodies Overcomes Drug Resistance Across EGFR Mutations in Exons 19, 20, and 21.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Annual average exposure to ambient air pollution, polygenic risk, and incidence of major chronic diseases: a large-scale prospective cohort study.Human genetics · 2026Article
- Comprehensive Genomic Analysis of Normal and Cancer Cells Elucidates the Elevated Mutational Burden in Cancer.Cancer research · 2026Article
- Wildfire smoke PMCancer epidemiology · 2026Article
- Plasma proteomic profiles associated with low-dose computed tomography findings and incident lung cancer: a prospective pilot study.Translational lung cancer research · 2026Article
- Multifocal ground-glass opacities in lung cancer: a narrative review of genomic evolution, immune ecology, and biology-informed clinical management.Journal of thoracic disease · 2026Review
- Review
- Associations of Outdoor Air Pollution With Incidence of Cancers Other Than Lung Cancer in a Large US Prospective Cohort.International journal of cancer · 2026Article
- Assessment of clinical and biological characteristics by pathological subtypes of lung adenocarcinoma.General thoracic and cardiovascular surgery · 2026Article
- Health effects of air pollution on chronic respiratory diseases.The Korean journal of internal medicine · 2026Review
- Reply to 'Clarifying causal and translational inference in studies of ambient PMBritish journal of cancer · 2026Article
- The Evolution of Polyclonal Competition in Aging Hematopoiesis.Cancer discovery · 2026Article
- Breathing carcinogens: PMJournal of thoracic disease · 2026Review
337 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
72 authors at 20 institutions in 15 countries.
William Hill *Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Emilia L Lim *Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Clare E Weeden *Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Claudia LeeCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-1715-2265
Marcellus AugustineCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Kezhong ChenCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Feng-Che KuanDepartment of Hematology and Oncology, Chang Gung Memorial Hospital, Chiayi Branch, Chiayi, Taiwan.
Fabio MarongiuDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Edward J EvansDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0001-8120-3755
David A MooreCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-6296-1312
Felipe S RodriguesTumour-Host Interaction Laboratory, The Francis Crick Institute, London, UK.
Oriol PichCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-1956-1882
Bjorn BakkerCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-3095-7287
Hongui ChaCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Renelle MyersBC Cancer Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Febe van MaldegemOncogene Biology Laboratory, The Francis Crick Institute, London, UK.
Jesse BoumelhaOncogene Biology Laboratory, The Francis Crick Institute, London, UK.
Selvaraju VeeriahCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Andrew RowanCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Cristina Naceur-LombardelliCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Takahiro KarasakiCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0001-6863-2360
Monica SivakumarCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Swapnanil DeCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Deborah R CaswellCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Ai NaganoCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-2354-660X
James R M BlackCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Carlos Martínez-RuizCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.ORCID http://orcid.org/0000-0002-4817-0565
Min Hyung RyuDepartment of Medicine, Division of Respiratory Medicine, Chan-Yeung Centre for Occupational and Environmental Respiratory Disease, Vancouver Coastal Health Research Institute, UBC, Vancouver, British Columbia, Canada.
Ryan D HuffDepartment of Medicine, Division of Respiratory Medicine, Chan-Yeung Centre for Occupational and Environmental Respiratory Disease, Vancouver Coastal Health Research Institute, UBC, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0002-6038-8217
Shijia LiDepartment of Medicine, Division of Respiratory Medicine, Chan-Yeung Centre for Occupational and Environmental Respiratory Disease, Vancouver Coastal Health Research Institute, UBC, Vancouver, British Columbia, Canada.
Marie-Julie FavéOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Alastair MagnessCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Alejandro Suárez-BonnetDepartment of Pathobiology and Population Sciences, The Royal Veterinary College, Hatfield, UK.ORCID http://orcid.org/0000-0003-0296-5896
Simon L PriestnallDepartment of Pathobiology and Population Sciences, The Royal Veterinary College, Hatfield, UK.ORCID http://orcid.org/0000-0002-6027-1879
Margreet LüchtenborgNational Disease Registration Service (NDRS), NHS England, Leeds, UK.
Katrina LavelleNational Disease Registration Service (NDRS), NHS England, Leeds, UK.
Joanna PethickNational Disease Registration Service (NDRS), NHS England, Leeds, UK.
Steven HardyNational Disease Registration Service (NDRS), NHS England, Leeds, UK.
Fiona E McRonaldNational Disease Registration Service (NDRS), NHS England, Leeds, UK.ORCID http://orcid.org/0000-0001-7226-9461
Meng-Hung LinHealth Information and Epidemiology Laboratory, Chang-Gung Memorial Hospital, Chiayi, Taiwan.ORCID http://orcid.org/0000-0002-8594-3360
Clara I TroccoliDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Moumita GhoshDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
York E MillerDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Daniel T MerrickDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Robert L KeithDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Maise Al BakirCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-0846-8332
Chris BaileyCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Mark S HillCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-0718-8934
Lao H SaalSAGA Diagnostics, Lund, Sweden.
Yilun ChenSAGA Diagnostics, Lund, Sweden.
Anthony M GeorgeSAGA Diagnostics, Lund, Sweden.ORCID http://orcid.org/0000-0001-5680-8664
Christopher AbboshCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.ORCID http://orcid.org/0000-0002-8983-1382
Nnennaya KanuCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Se-Hoon LeeDivision of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID http://orcid.org/0000-0002-9219-3350
Nicholas McGranahanCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.ORCID http://orcid.org/0000-0001-9537-4045
Christine D BergEarly Cancer Detection Consultant, Bethesda, MD, USA.
Peter SasieniComprehensive Cancer Centre, King's College London, London, UK.ORCID http://orcid.org/0000-0003-1509-8744
Richard HoulstonDivision of Genetics and Epidemiology, Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0002-5268-0242
Clare TurnbullDivision of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
Stephen LamBC Cancer Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Philip AwadallaOntario Institute for Cancer Research, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-9946-6393
Eva GrönroosCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0001-8303-5409
Julian DownwardOncogene Biology Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-2331-4729
Tyler JacksDavid H. Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5785-8911
Christopher CarlstenDepartment of Medicine, Division of Respiratory Medicine, Chan-Yeung Centre for Occupational and Environmental Respiratory Disease, Vancouver Coastal Health Research Institute, UBC, Vancouver, British Columbia, Canada.
Ilaria MalanchiTumour-Host Interaction Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-4867-3311
Allan HackshawCancer Research UK and UCL Cancer Trials Centre, London, UK.ORCID http://orcid.org/0000-0002-5570-5070
Kevin LitchfieldCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.ORCID http://orcid.org/0000-0002-3725-0914
TRACERx Consortium
James DeGregoriDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-1287-1976
Mariam Jamal-HanjaniCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.ORCID http://orcid.org/0000-0003-1212-1259
Charles SwantonCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK. Charles.Swanton@crick.ac.uk.ORCID http://orcid.org/0000-0002-4299-3018
The Francis Crick Institute · GBCancer Research UK · GBLondon Cancer · GBRoyal London Hospital · GBGuy's and St Thomas' NHS Foundation Trust · GBManchester University NHS Foundation Trust · GBUniversity Hospitals of Leicester NHS Trust · GBSwansea Bay University Health Board · GBUniversity Hospitals Birmingham NHS Foundation Trust · GBUniversity of Leicester · GBUniversity Hospital Southampton NHS Foundation Trust · GBInstitute of Cancer Research · GBGolden Jubilee National Hospital · GBUniversity College London · GBUniversity of Colorado Anschutz Medical Campus · USAberdeen Royal Infirmary · GBNHS EnglandUniversity College Hospital · GBUniversity of Manchester · GBVancouver Coastal Health · CA
Funding
University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0MTraining in Translational Research of Lung, Head and Neck CancerT32CA174648 · NCI · UNIVERSITY OF COLORADO DENVER · PI KARAM, SANA D · 2013 to 2022
$4.2MTraining Program in Cancer BiologyT32CA190216 · NCI · UNIVERSITY OF COLORADO DENVER · PI Craig T. Jordan · 2016 to 2026
$3.5M(PQ1) Progenitor cell malfunction, mutations and changes in microenvironment: A dynamic risk spectrum for cancer evolutionR01CA219893 · NCI · UNIVERSITY OF COLORADO DENVER · PI GHOSH, MOUMITA, MILLER, YORK E · 2017 to 2022
$2.3MDissecting the Role of Inflammation in Smoking and Aging Associated Lung CancersI01BX004495 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI DEGREGORI, JAMES V · 2019 to 2023
–BLRD VA I01 BX004495Cancer Research UK 17786Cancer Research UK 21999Cancer Research UK 25349Cancer Research UK 25514Cancer Research UK 29569Cancer Research UK 30025Cancer Research UK CC2041Cancer Research UK CTRNBC-2022/100001Cancer Research UK EDDPJT-NOV22/100042Medical Research Council MR/P014712/1Medical Research Council MR/V033077/1Medical Research Council MR/W025051/1NCI NIH HHS P30 CA046934NCI NIH HHS R01 CA219893NCI NIH HHS T32 CA174648NCI NIH HHS T32 CA190216Wellcome Trust CC2041
Abstract
A complete understanding of how exposure to environmental substances promotes cancer formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two-step process: an initiating step that induces mutations in healthy cells, followed by a promoter step that triggers cancer development
Indexed as
Adenocarcinoma of LungAir PollutantsAir PollutionCell Transformation, NeoplasticLung NeoplasmsAlveolar Epithelial CellsAnimalsCohort StudiesEnvironmental ExposureErbB ReceptorsInterleukin-1betaMacrophages, AlveolarMiceParticle SizeParticulate MatterAir PollutantsEGFR protein, humanErbB ReceptorsIL1B protein, mouseInterleukin-1betaParticulate Matter
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT07383454ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.