ArticleScientific reports2023
Prosocial behavior, social reward and affective state discrimination in adult male and female mice.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- On the importance of including both sexes in animal studies - insights from home-cage monitoring.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Psilocybin modulates social behaviour in male and female mice in a time-dependent manner.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Strain-Dependent Network Activity Differences Underlie Social Decision-Making in Male Mice.eNeuro · 2026Article
- Mu or delta opioid receptor antagonists increase the expression of social conditioned place preference in early adolescent mice.Psychopharmacology · 2026Article
- Changes in social reward across adolescence in male mice.Scientific reports · 2025Article
- Environment impacts sexual preference: dopamine sends signals under pressure to decide which sex you like.Signal transduction and targeted therapy · 2025Article
- Adolescent mice exhibit lower reward sensitivity than adults.Frontiers in behavioral neuroscience · 2025Article
- Novel behavioral tasks for the measurement of social motivation in mice: a comparison across strains.Frontiers in behavioral neuroscience · 2025Article
- Editorial: Animal-friendly methods for rodent behavioral testing in neuroscience research.Frontiers in behavioral neuroscience · 2024Article
- In search of prosociality in rodents: A scoping review.PloS one · 2024Article
- Social Interaction Is Less Rewarding in Adult Female than in Male Mice.Brain sciences · 2023Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prosocial behavior, defined as voluntary behavior intended to benefit another, has long been regarded as a primarily human characteristic. In recent years, it was reported that laboratory animals also favor prosocial choices in various experimental paradigms, thus demonstrating that prosocial behaviors are evolutionarily conserved. Here, we investigated prosocial choices in adult male and female C57BL/6 laboratory mice in a task where a subject mouse was equally rewarded for entering any of the two compartments of the experimental cage, but only entering of the compartment designated as "prosocial" rewarded an interaction partner. In parallel we have also assessed two traits that are regarded as closely related to prosociality: sensitivity to social reward and the ability to recognize the affective state of another individual. We found that female, but not male, mice increased frequency of prosocial choices from pretest to test. However, both sexes showed similar rewarding effects of social contact in the conditioned place preference test, and similarly, there was no effect of sex on affective state discrimination measured as the preference for interaction with a hungry or relieved mouse over a neutral animal. These observations bring interesting parallels to differences between sexes observed in humans, and are in line with reported higher propensity for prosocial behavior in human females, but differ with regard to sensitivity to social stimuli in males.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.