Evidence map›Paper›PMID 37019859›Full record

SynthesisJournal of neurogastroenterology and motility2023

Small Intestinal Bacterial Overgrowth Complicating Gastrointestinal Manifestations of Systemic Sclerosis: A Systematic Review and Meta-analysis.

Ayesha Shah, Veenaa Pakeerathan, Michael P Jones, Purna C Kashyap, Kate Virgo, Thomas Fairlie, Mark Morrison, Uday C Ghoshal, Gerald J Holtmann

Open access · diamondAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of neurogastroenterology and motility, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Ayesha ShahFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Veenaa PakeerathanFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Michael P JonesSchool of Psychological Sciences, Macquarie University, Sydney, NSW, Australia.
Purna C KashyapDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Kate VirgoFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Thomas FairlieDepartment of Gastroenterology and Hepatology, Princess Alexandra Hospital, Woolloongabba, QLD, Australia.
Mark MorrisonFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Uday C GhoshalDepartment of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Gerald J HoltmannFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Princess Alexandra Hospital · AUThe University of Queensland · AUMacquarie University · AUMayo Clinic in Arizona · USSanjay Gandhi Post Graduate Institute of Medical Sciences · IN

Funding

Mechanisms of alteration of GI physiology by gut microbesR01DK114007 · NIDDK · MAYO CLINIC ROCHESTER · PI Purna C Kashyap · 2017 to 2026
$4.7M
NIDDK NIH HHS R01 DK114007
6 · The paper itself

Abstract

Background/Aims: Systemic sclerosis (SSc) often is complicated by small intestinal bacterial overgrowth (SIBO). A systematic review and meta-analysis thus examined the prevalence of SIBO in SSc (SSc-subtypes), identify risk factors for SIBO in SSc and the effects of concomitant SIBO on gastrointestinal symptoms in SSc. Methods: We searched electronic databases until January-2022 for studies providing prevalence rates of SIBO in SSc. The prevalence rates, odds ratio (OR) and 95% confidence intervals (CI) of SIBO in SSc and controls were calculated. Results: The final dataset comprised 28 studies with 1112 SSc-patients and 335 controls. SIBO prevalence in SSc-patients was 39.9% (95% CI, 33.1-47.1; Conclusions: There is a 10-fold increased prevalence of SIBO in SSc, with similar SIBO prevalence rates in SSc-subtypes. Antimicrobial therapy of SIBO-positive SSc-patients with diarrhea should be considered. However, the results must be interpreted with caution due to substantial unexplained heterogeneity in the prevalence studies, and the low sensitivity and specificity of the diagnostic tests suggesting that the reliability of the evidence may be low.

Indexed as

Bacterial overgrowthBreath testsLimited sclerodermaPrevalenceSmall intestinal bacterial overgrowthSystemic sclerosis

Identifiers

PMID37019859
PMCPMC10083111
OpenAlexW4362637447

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.