Evidence map›Paper›PMID 37019808›Full record

ArticleAmerican journal of surgery2023

Thyroid cancer pathologic upstaging: Frequency and related factors.

Jacqueline M Soegaard Ballester, Caitlin B Finn, Sara P Ginzberg, Rachel R Kelz, Heather Wachtel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jacqueline M Soegaard BallesterDepartment of Surgery, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, USA. Electronic address: Jacqueline.Soegaard@pennmedicine.upenn.edu.
Caitlin B FinnDepartment of Surgery, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, USA. Electronic address: Caitlin.Finn@pennmedicine.upenn.edu.
Sara P GinzbergDepartment of Surgery, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, USA. Electronic address: Sara.Ginzberg@pennmedicine.upenn.edu.
Rachel R KelzDepartment of Surgery, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, USA; Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA, USA. Electronic address: Rachel.Kelz@pennmedicine.upenn.edu.
Heather WachtelDepartment of Surgery, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, USA; Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA, USA. Electronic address: Heather.Wachtel@pennmedicine.upenn.edu.
Hospital of the University of Pennsylvania · US

Funding

Institutional Clinical and Translational Science AwardKL2TR001879 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$13.7M
Parathyroid Tumor Clonal Status as a Biomarker in Primary HyperparathyroidismR01CA228399 · NCI · WASHINGTON UNIVERSITY · PI OLSON, JOHN A. · 2019 to 2023
$3.2M
Using Outcomes to Guide Treatment of Surgical EmergenciesR01AG060612 · NIA · UNIVERSITY OF PENNSYLVANIA · PI KELZ, RACHEL · 2019 to 2023
$2.7M
SURGICAL ONCOLOGY RESEARCH TRAINING PROGRAM AT PENNT32CA251063 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Ronald P. Dematteo · 2020 to 2026
$2.6M
A genotype-phenotype study of germline succinate dehydrogenase pathogenic variantsK08CA270385 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Heather Wachtel · 2022 to 2026
$967k
NCATS NIH HHS KL2 TR001879NCI NIH HHS K08 CA270385NCI NIH HHS R01 CA228399NCI NIH HHS T32 CA251063NIA NIH HHS R01 AG060612
6 · The paper itself

Abstract

introductionHistopathologic assessment of thyroid tumors can lead to stage migration. We assessed frequency of pathologic upstaging, and associations with patient and tumor factors.

methodsPrimary thyroid cancers treated between 2013 and 2015 were included from our institutional cancer registry. For tumor, nodal, and summary stage, upstaging was present when final pathologic stage was greater than clinical staging. Multivariate logistic regression and Chi-squared tests were performed.

results5,351 resected thyroid tumors were identified. Upstaging rates for tumor, nodal, and summary stage were 17.5% (n = 553/3156), 18.0% (n = 488/2705), and 10.9% (n = 285/2607), respectively. Age, Asian race, days to surgery, lymphovascular invasion, and follicular histology were significantly associated. Upstaging was significantly more common after total vs partial thyroidectomy, for tumor (19.4% vs 6.2%, p < 0.001), nodal (19.3% vs 6.4%, p < 0.001), and summary stages (12.3% vs 0.7%, p < 0.001).

conclusionsPathologic upstaging occurs in a considerable proportion of thyroid tumors, most commonly after total thyroidectomy. These findings can inform patient counseling.

Indexed as

Lung NeoplasmsThyroid NeoplasmsHumansNeoplasm StagingPneumonectomyThyroidectomyCancer stagingCounselingStage migrationThyroid cancerUpstaging

Identifiers

PMID37019808
PMCPMC10518023
OpenAlexW4360842353

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.