Evidence map›Paper›PMID 37019623›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration.

Jessica A Lawrence, Patricia Aguilar-Calvo, Daniel Ojeda-Juárez, Helen Khuu, Katrin Soldau, Donald P Pizzo, Jin Wang, Adela Malik, Timothy F Shay, Erin E Sullivan and 13 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 9 citations in OpenAlex.

  1. ESCRT-0 regulates AMPA receptor currents and CabioRxiv : the preprint server for biology · 2026
    Article
  2. PrPStem cell reports · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. The ESCRT Pathway's Role in Prion Diseases and Beyond.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 2 countries.

Jessica A LawrenceDepartment of Pathology, University of California, San Diego, La, Jolla, California, 92093.
Patricia Aguilar-CalvoDepartment of Pathology, University of California, San Diego, La, Jolla, California, 92093.
Daniel Ojeda-JuárezDepartment of Pathology, University of California, San Diego, La, Jolla, California, 92093.
Helen KhuuDepartment of Pathology, University of California, San Diego, La, Jolla, California, 92093.
Katrin SoldauDepartment of Pathology, University of California, San Diego, La, Jolla, California, 92093.
Donald P PizzoDepartment of Pathology, University of California, San Diego, La, Jolla, California, 92093.
Jin WangDepartment of Pathology, University of California, San Diego, La, Jolla, California, 92093.
Adela MalikDepartment of Pathology, University of California, San Diego, La, Jolla, California, 92093.ORCID 0000-0001-6827-3935
Timothy F ShayDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125.ORCID 0000-0001-6591-3271
Erin E SullivanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125.
Brent AulstonDepartment of Neurosciences, University of California, San Diego, La Jolla, California 92093.
Seung Min SongDepartment of Pathology, University of California, San Diego, La, Jolla, California, 92093.
Julia A CallenderDepartment of Pathology, University of California, San Diego, La, Jolla, California, 92093.
Henry SanchezDepartment of Pathology, University of California, San Francisco, San Francisco, California 94143.
Michael D GeschwindDepartment of Neurology, Memory and Aging Center, University of California, San Francisco (UCSF), San Francisco, California 94143.
Subhojit RoyDepartment of Pathology, University of California, San Diego, La, Jolla, California, 92093.
Robert A RissmanDepartment of Neurosciences, University of California, San Diego, La Jolla, California 92093.ORCID 0000-0001-9245-8278
JoAnn TrejoDepartment of Pharmacology, University of California, San Diego, La Jolla, California 92093.
Nobuyuki TanakaDivision of Tumor Immunobiology, Miyagi Cancer Center Research Institute, Natori 981-1293, Japan.
Chengbiao WuDepartment of Neurosciences, University of California, San Diego, La Jolla, California 92093.ORCID 0000-0002-3660-088X
Xu ChenDepartment of Neurosciences, University of California, San Diego, La Jolla, California 92093.
Gentry N PatrickDepartment of Biology, University of California, San Diego, La Jolla, California 92093.
Christina J SigurdsonDepartment of Pathology, University of California, San Diego, La, Jolla, California, 92093 csigurdson@health.ucsd.edu.
University of California San Diego · USCalifornia Institute of Technology · USUniversity of California, San Francisco · USTohoku University · JPUC San Diego Health System · US

Funding

UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GUERRY Marie PEAVY · 2019 to 2026
$34.9M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Predicting progression of human prion diseaseR01AG031189 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GESCHWIND, MICHAEL D · 2008 to 2017
$5.7M
Mechanisms of Prion Aggregation and Species BarriersR01NS069566 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ESKO, JEFFREY D, RAVITS, JOHN · 2011 to 2025
$5.7M
Tracking longitudinal change in presymptomatic genetic prion disease (TLC-Pre-gPrD)R01AG062562 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GESCHWIND, MICHAEL D · 2019 to 2023
$5.4M
B-Synuclein as a Treatment for Lewy Body DiseaseR01AG018440 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RISSMAN, ROBERT · 2001 to 2021
$5.2M
Cell Signaling by Protease-activated G Protein-coupled ReceptorsR35GM127121 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joann Trejo · 2018 to 2026
$4.5M
Mechanisms of Prion SpreadR01NS076896 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIGURDSON, CHRISTINA · 2012 to 2021
$3.4M
Mechanisms of Prion Spread and Neuronal ToxicityR37NS076896 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Christina Sigurdson · 2023 to 2026
$2.6M
Pathophysiologic roles of alpha-synuclein at the synapseR01NS111978 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROY, SUBHOJIT · 2019 to 2023
$2.4M
Multidisciplinary training in basic and translational Alzheimer's disease researchT32AG066596 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 2020 to 2024
$2.2M
NIA NIH HHS K99 AG061251NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG018440NIA NIH HHS R01 AG031189NIA NIH HHS R01 AG062562NIA NIH HHS R56 AG055619NIA NIH HHS RF1 AG072053NIA NIH HHS T32 AG066596NIGMS NIH HHS R35 GM127121NIH HHS S10 OD023527NINDS NIH HHS F31 NS103588NINDS NIH HHS P30 NS047101NINDS NIH HHS R01 NS069566NINDS NIH HHS R01 NS076896NINDS NIH HHS R01 NS111978NINDS NIH HHS R01 NS121992NINDS NIH HHS R37 NS076896NINDS NIH HHS RF1 NS121992
6 · The paper itself

Abstract

Endolysosomal defects in neurons are central to the pathogenesis of prion and other neurodegenerative disorders. In prion disease, prion oligomers traffic through the multivesicular body (MVB) and are routed for degradation in lysosomes or for release in exosomes, yet how prions impact proteostatic pathways is unclear. We found that prion-affected human and mouse brain showed a marked reduction in Hrs and STAM1 (ESCRT-0), which route ubiquitinated membrane proteins from early endosomes into MVBs. To determine how the reduction in ESCRT-0 impacts prion conversion and cellular toxicity

Indexed as

Neurodegenerative DiseasesPrion DiseasesPrionsAnimalsEndosomal Sorting Complexes Required for TransportFemaleHumansMaleMiceNeuronsPrion ProteinsReceptors, AMPAEndosomal Sorting Complexes Required for TransportPrion ProteinsPrionsReceptors, AMPAamyloidESCRTneurodegenerationproteostasissynapseubiquitin

Identifiers

PMID37019623
PMCPMC10219035
OpenAlexW4362638896

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.