SynthesisBMJ (Clinical research ed.)2023
Ambient air pollution and clinical dementia: systematic review and meta-analysis.
Synthesis in BMJ (Clinical research ed.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 8 syntheses or guidelines pooled it, 166 citations in OpenAlex.
- Airborne pollutants and risk of neurodegenerative diseases: a global systematic review and meta-analysis.Alzheimer's research & therapy · 2026Pooled it
- Long-term exposure to ambient particulate matter and its association with Alzheimer's disease: influencing factors and a systematic review with meta-analysis.Frontiers in public health · 2026Pooled it
- Effects of air pollutants on the incidence, progression, and mortality of idiopathic pulmonary fibrosis: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Prognostic value of FIB-4 and NFS for cardiovascular events in patients with and without NAFLD.BMC public health · 2025Pooled it
- A State of the Science Review of Wildfire-Specific Fine Particulate Matter Data Sources, Methods, and Models.Environmental health perspectives · 2025Pooled it
- A systematic review with a Burden of Proof meta-analysis of health effects of long-term ambient fine particulate matter (PMNature aging · 2025Pooled it
- Ambient air pollution and urological cancer risk: A systematic review and meta-analysis of epidemiological evidence.Nature communications · 2024Pooled it
- Occupational and domestic exposure associations with cerebral small vessel disease and vascular dementia: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Environmental Pollution, Biomarkers, and Dementia: An Evidence Review.International journal of molecular sciences · 2026Review
- Aging in a highly polluted world: challenges and solutions to prevent Alzheimer's disease.Archives of toxicology · 2026Review
- Urbanicity, Neighborhood Conditions, and Dementia Mortality.JAMA network open · 2026Article
- Revisiting 'environmental effects': Directions for multidisciplinary investigations of air quality and psychopathology.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Air Pollution and Alzheimer's Disease: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Effects of non-thermal plasma on disinfection of indoor air and reduction of particulate matter.Scientific reports · 2026Article
- 2-aminobutyrate mediates the impact of air pollution on blood biomarkers of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Accelerated biological aging and brain structural alterations linking air pollution to dementia risk: a prospective cohort study.The journal of nutrition, health & aging · 2026Article
- Sector-specific Long-term Associations Between Transportation, Industrial, and Residential Combustion Air Pollutant Mixtures (PMEnvironmental epidemiology (Philadelphia, Pa.) · 2026Article
- Long-Term Exposure to Air Pollution and Risk and Prognosis of Motor Neuron Disease.JAMA neurology · 2026Article
- Racial and ethnic differences in the impact of air pollution on the risk of Alzheimer's disease and related dementias in the Multiethnic Cohort Study.Environment international · 2026Article
- The sex-specific association between long-term PM2.5 exposure and incident dementia in community-dwelling older adults in Australia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo investigate the role of air pollutants in risk of dementia, considering differences by study factors that could influence findings.
designSystematic review and meta-analysis. DATA SOURCES: EMBASE, PubMed, Web of Science, Psycinfo, and OVID Medline from database inception through July 2022. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Studies that included adults (≥18 years), a longitudinal follow-up, considered US Environmental Protection Agency criteria air pollutants and proxies of traffic pollution, averaged exposure over a year or more, and reported associations between ambient pollutants and clinical dementia. Two authors independently extracted data using a predefined data extraction form and assessed risk of bias using the Risk of Bias In Non-randomised Studies of Exposures (ROBINS-E) tool. A meta-analysis with Knapp-Hartung standard errors was done when at least three studies for a given pollutant used comparable approaches.
results2080 records identified 51 studies for inclusion. Most studies were at high risk of bias, although in many cases bias was towards the null. 14 studies could be meta-analysed for particulate matter <2.5 µm in diameter (PM
conclusionPM SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42021277083.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.