Evidence map›Paper›PMID 37019444›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2023

Asymmetric triplex metallohelices stabilise DNA G-quadruplexes in promoter oncogene sequences and efficiently reduce their expression in cancer cells.

Jaroslav Malina, Hana Kostrhunova, Hualong Song, Peter Scott, Viktor Brabec

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jaroslav MalinaCzech Academy of Sciences, Institute of Biophysics, Brno, Czech Republic.
Hana KostrhunovaCzech Academy of Sciences, Institute of Biophysics, Brno, Czech Republic.
Hualong SongDepartment of Chemistry, University of Warwick, Coventry, UK.
Peter ScottDepartment of Chemistry, University of Warwick, Coventry, UK.
Viktor BrabecCzech Academy of Sciences, Institute of Biophysics, Brno, Czech Republic.
Czech Academy of Sciences, Institute of Biophysics · CZUniversity of Warwick · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some metallo-supramolecular helical assemblies with size, shape, charge and amphipathic architectures similar to short cationic α-helical peptides have been shown to target and stabilise DNA G-quadruplexes (G4s)

Indexed as

G-QuadruplexesNeoplasmsDNAHumansOncogenesPromoter Regions, GeneticDNADNA synthesisexpression of oncogenesG-quadruplexesMetallohelicestelomeres

Identifiers

PMID37019444
PMCPMC10078150
OpenAlexW4362636752

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.