Observational studyHeart & lung : the journal of critical care
Predictive factors and clinical impact of ICU-acquired weakness on functional disability in mechanically ventilated patients with COVID-19.
Observational study in Heart & lung : the journal of critical care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Pooled it
- Application of lower limb exoskeleton robots in elderly patients with ICU-acquired weakness: a prospective clinical study.BMC geriatrics · 2026Trial
- Risk factors for ICU-acquired weakness in patients undergoing mechanical ventilation: a systematic review and meta-analysis.Journal of thoracic disease · 2025Article
- Early Neuromuscular Electrical Stimulation and In-Bed Leg Cycling Preserve Quadriceps Femoris Muscle Thickness in Critically Ill Patients.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2025Article
- Risk factors of ICU-acquired weakness in sepsis patients.Pakistan journal of medical sciences · 2025Article
- Neurological complications caused by SARS-CoV-2.Clinical microbiology reviews · 2024Review
- Which factors are associated with acquired weakness in the ICU? An overview of systematic reviews and meta-analyses.Journal of intensive care · 2024Review
- Outcome Measures to Evaluate Functional Recovery in Survivors of Respiratory Failure: A Scoping Review.CHEST critical care · 2024Article
- Activity of Daily Living and Walking Ability of Patients with Severe COVID-19 at Discharge from an Acute Care Hospital.Progress in rehabilitation medicine · 2024Article
- Effects of repetitive peripheral magnetic stimulation on a patient with severe lower limb muscle weakness due to coronavirus disease-2019.Japanese journal of comprehensive rehabilitation science · 2024Article
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Authors and funding
18 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with critical COVID-19 often require invasive mechanical ventilation (IMV) and admission to the intensive care unit (ICU), resulting in a higher incidence of ICU-acquired weakness (ICU-AW) and functional decline.
objectiveThis study aimed to examine the causes of ICU-AW and functional outcomes in critically ill patients with COVID-19 who required IMV.
methodsThis prospective, single-center, observational study included COVID-19 patients who required IMV for ≥48 h in the ICU between July 2020 and July 2021. ICU-AW was defined as a Medical Research Council sum score <48 points. The primary outcome was functional independence during hospitalization, defined as an ICU mobility score ≥9 points.
resultsA total of 157 patients (age: 68 [59-73] years, men: 72.6%) were divided into two groups (ICU-AW group; n = 80 versus non-ICU-AW; n = 77). Older age (adjusted odds ratio [95% confidence interval]: 1.05 [1.01-1.11], p = 0.036), administration of neuromuscular blocking agents (7.79 [2.87-23.3], p < 0.001), pulse steroid therapy (3.78 [1.49-10.1], p = 0.006), and sepsis (7.79 [2.87-24.0], p < 0.001) were significantly associated with ICU-AW development. In addition, patients with ICU-AW had significantly longer time to functional independence than those without ICU-AW (41 [30-54] vs 19 [17-23] days, p < 0.001). The development of ICU-AW was associated with delayed time to functional independence (adjusted hazard ratio: 6.08; 95% CI: 3.05-12.1; p < 0.001).
conclusionsApproximately half of the patients with COVID-19 requiring IMV developed ICU-AW, which was associated with delayed functional independence during hospitalization.
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