Evidence map›Paper›PMID 37018203›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Toward quantification of hypoxia using fluorinated Eu

S A Amali S Subasinghe, Caitlyn J Ortiz, Jonathan Romero, Cassandra L Ward, Alexander G Sertage, Lyazat Kurenbekova, Jason T Yustein, Robia G Pautler, Matthew J Allen

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Single Molecule EuJournal of the American Chemical Society · 2026
    Article
  3. Article
  4. Article
  5. Hypoxia Imaging as a Radiomics Signature in Tumors Using NovelbioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

S A Amali S SubasingheDepartment of Chemistry, Wayne State University, Detroit, MI 48202.ORCID 0000-0002-1415-7717
Caitlyn J OrtizDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030.
Jonathan RomeroDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030.
Cassandra L WardLumigen Instrument Center, Wayne State University, Detroit, MI 48202.
Alexander G SertageDepartment of Chemistry, Wayne State University, Detroit, MI 48202.
Lyazat KurenbekovaDepartment of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX 77030.
Jason T YusteinAflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA 30322.ORCID 0000-0002-2052-0527
Robia G PautlerDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0001-7952-8526
Matthew J AllenDepartment of Chemistry, Wayne State University, Detroit, MI 48202.ORCID 0000-0002-6868-8759
Baylor College of Medicine · USWayne State University · USEmory University · US

Funding

Intratumoral imaging of hypoxia using 1H- and 19F-MRI with redox-responsive Eu-based contrast agentsR01EB026453 · NIBIB · WAYNE STATE UNIVERSITY · PI ALLEN, MATTHEW J, PAUTLER, ROBIA G · 2018 to 2021
$2.7M
Library Synthesis and Screening of Eu(II)-Based Contrast AgentsR01EB027103 · NIBIB · WAYNE STATE UNIVERSITY · PI ALLEN, MATTHEW J · 2019 to 2022
$1.4M
Chemistry Biology Interface Training Program at Wayne State UniversityT32GM142519 · NIGMS · WAYNE STATE UNIVERSITY · PI CHOW, CHRISTINE S, PFLUM, MARY KAY H · 2021 to 2025
$1.2M
500 MHz NMR SpectrometerS10OD028488 · OD · WAYNE STATE UNIVERSITY · PI ALLEN, MATTHEW J · 2021 to 2021
$600k
NIBIB NIH HHS R01 EB026453NIBIB NIH HHS R01 EB027103NIGMS NIH HHS T32 GM142519NIH HHS S10 OD028488
6 · The paper itself

Abstract

Hypoxia is a prognostic biomarker of rapidly growing cancers, where the extent of hypoxia is an indication of tumor progression and prognosis; therefore, hypoxia is also used for staging while performing chemo- and radiotherapeutics for cancer. Contrast-enhanced MRI using Eu

Indexed as

FluorineNeoplasmsHumansHypoxiaMagnetic Resonance ImagingOxygenFluorineOxygenhypoxiaMRIratiometricresponsive contrast agents

Identifiers

PMID37018203
PMCPMC10104500
OpenAlexW4362602162

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.