ArticleSurgery today2023
Risk factors for postoperative anastomotic leakage after repair of esophageal atresia: a retrospective nationwide database study.
Article in Surgery today, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Respiratory Morbidity After Repair of Type C Esophageal Atresia with Tracheoesophageal Fistula: A Pediatric Case Series.Journal of clinical medicine · 2026Article
- An atypical variant of congenital bronchoesophageal fistula associated with esophageal atresia and right main bronchial atresia and right lung hypoplasia in a preterm neonate: a case report.Journal of medical case reports · 2026Article
- Modified thoracoscopic anastomosis of esophageal atresia with tracheoesophageal fistula.Pediatric surgery international · 2026Article
- Early postoperative inflammatory markers associated with anastomotic leakage after repair of congenital esophageal atresia.BMC pediatrics · 2026Article
- Long-term impact of anastomotic leakage following esophageal atresia repair: feeding outcomes, esophageal morbidity, and reinterventions.Frontiers in pediatrics · 2026Article
- Does thoracoscopic repair of type C esophageal atresia require emergency treatment?BMC surgery · 2025Article
- Predictive value of early postoperative blood lipid metabolism for anastomotic leakage after esophageal cancer surgery.American journal of translational research · 2024Article
- Conservative Management of Anastomotic Leak after Repair of Type C Esophageal Atresia: A Retrospective Audit.Journal of Indian Association of Pediatric SurgeonsArticle
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
purposePostoperative anastomotic leakage is the most frequent short-term complication of esophageal atresia repair in neonates. We conducted this study using a nationwide surgical database in Japan to identify the risk factors for anastomotic leakage in neonates undergoing esophageal atresia repair.
methodsNeonates diagnosed with esophageal atresia between 2015 and 2019 were identified in the National Clinical Database. Postoperative anastomotic leakage was compared among patients to identify the potential risk factors, using univariate analysis. Multivariable logistic regression analysis included sex, gestational age, thoracoscopic repair, staged repair, and procedure time as independent variables.
resultsWe identified 667 patients, with an overall leakage incidence of 7.8% (n = 52). Anastomotic leakage was more likely in patients who underwent staged repairs than in those who did not (21.2% vs. 5.2%, respectively) and in patients with a procedure time > 3.5 h than in those with a procedure time < 3.5 h (12.6% vs. 3.0%, respectively; p < 0.001). Multivariable logistic regression analysis identified staged repair (odds ratio [OR] 4.89, 95% confidence interval [CI] 2.22-10.16, p < 0.001) and a longer procedure time (OR 4.65, 95% CI 2.38-9.95, p < 0.001) as risk factors associated with postoperative leakage.
conclusionStaged procedures and long operative times are associated with postoperative anastomotic leakage, suggesting that leakage is more likely after complex esophageal atresia repair and that such patients require refined treatment strategies.
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