ArticleEuropean radiology2023
Correlation of R2* with fat fraction and bone mineral density and its role in quantitative assessment of osteoporosis.
Article in European radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Predictive Effect of Preoperative Bone Marrow Fat Fraction on Postoperative Bone Mineral Density After Bariatric Surgery: a Prospective Cohort Study.Obesity surgery · 2026Article
- Article
- Evaluation of the severity of lumbar osteoporosis in patients with type 2 diabetes mellitus using q-Dixon magnetic resonance imaging.American journal of translational research · 2026Article
- Role of vertebral fat fraction and R2* based on fat analysis and calculation technique in the quantitative assessment of osteoporosis.BMC musculoskeletal disorders · 2025Article
- Iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL-IQ) for evaluation of early bone mass changes in ageing osteoporosis patients.Magnetic resonance letters · 2025Article
- Exploring Fat Fraction and Vertebral Bone Quality Score in Lumbar Spine Magnetic Resonance Imaging: A Cross-Sectional Study on Associations and Clinical Implication.Diagnostics (Basel, Switzerland) · 2025Article
- Radiological frontiers in understanding paraspinal muscle pathophysiology in chronic low back pain.Frontiers in medicine · 2025Review
- Quantitative magnetic resonance imaging of paraspinal muscles for assessing chronic non-specific low back pain in young adults: a prospective case-control study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- Systematic evaluation of vertebral bone quality score as an opportunistic screening method for BMD in spine surgery patients.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- Preoperative Prediction of New Vertebral Fractures after Vertebral Augmentation with a Radiomics Nomogram.Diagnostics (Basel, Switzerland) · 2023Article
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6 authors.
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Abstract
objectivesTo investigate the correlation of R2* with vertebral fat fraction (FF) and bone mineral density (BMD), and to explore its role in the quantitative assessment of osteoporosis (OP).
methodsA total of 83 patients with low back pain (59.77 ± 7.46 years, 30 males) were enrolled, which underwent lumbar MRI in IDEAL-IQ sequences and quantitative computed tomography (QCT) scanning within 48h. The FF, R2*, and BMD of all 415 lumbar vertebrae were respectively measured. According to BMD, all vertebrae were divided into BMD normal, osteopenia, and OP groups, and the difference of FF and R2* among groups was analyzed by one-way ANOVA. The correlation between R2*, FF, and BMD was analyzed by Pearson's test. Taking BMD as the gold standard, the efficacies for FF and R2* in diagnosis of OP and osteopenia were assessed by receiver operating characteristic curve, and their area under the curve (AUC) was compared with DeLong's test.
resultsThe FF and R2* were statistically different among groups (F values of 102.521 and 11.323, both p < 0.05), and R2* were significantly correlated with FF and BMD, respectively (r values of -0.219 and 0.290, both p < 0.05). In diagnosis of OP and osteopenia, the AUCs were 0.776 and 0.778 for FF and 0.638 and 0.560 for R2*, and the AUCs of R2* were lower than those of FF, with Z values of 4.030 and 4.087, both p < 0.001.
conclusionR2* is significantly correlated with FF and BMD and can be used as a complement to FF and BMD for quantitative assessment of OP. KEY POINTS: • R2* based on IDEAL-IQ sequences has a definite but weak linear relationship with FF and BMD. • FF is significantly correlated with BMD and can effectively evaluate BMAT. • R2* can be used as a complement to FF and BMD for fine quantification of bone mineral loss and bone marrow fat conversion.
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