Evidence map›Paper›PMID 37017333›Full record

ArticleJournal of neurophysiology2023

Elevated Gaussian-modeled beta power in the cortex characterizes aging, but not Parkinson's disease.

Apoorva Karekal, Samuel Stuart, Martina Mancini, Nicole C Swann

Open access · greenAbstract read
In one paragraph

Article in Journal of neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Apoorva KarekalDepartment of Human Physiology, University of Oregon, Eugene, Oregon, United States.ORCID 0000-0001-9566-2186
Samuel StuartDepartment of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle Upon Tyne, United Kingdom.
Martina ManciniDepartment of Neurology, Oregon Health and Science University, Portland, Oregon, United States.
Nicole C SwannDepartment of Human Physiology, University of Oregon, Eugene, Oregon, United States.ORCID 0000-0003-2463-5134
University of Oregon · USNorthumbria University · GBOregon Health & Science University · US

Funding

Body-Worn Sensors to Characterize & Treat Freezing of Gait in Parkinson's DiseaseR00HD078492 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MANCINI, MARTINA · 2016 to 2018
$701k
NICHD NIH HHS 5R00HD078492-04NICHD NIH HHS R00 HD078492Parkinson's Disease Foundation clinical research awardParkinson's Disease Foundation postdoctoral fellowship
6 · The paper itself

Abstract

Aging is a key risk factor for the development of Parkinson's disease (PD). PD is characterized by excessive synchrony of beta oscillations (13-30 Hz) in the basal ganglia thalamo-cortical network. However, cortical beta power is not reliably elevated in individuals with PD. Here, we sought to disentangle how resting cortical beta power compares in younger controls, older controls, and individuals with PD using scalp electroencephalogram (EEG) and a novel approach for quantifying beta power. Specifically, we used a Gaussian model to determine if sensorimotor beta power distinguishes these groups. In addition, we looked at the distribution of beta power across the entire cortex. Our findings showed that Gaussian-modeled beta power does not differentiate individuals with PD (on medication) from healthy younger or older controls in sensorimotor cortex. However, beta power (and not theta or alpha) was higher in healthy older versus younger controls. This effect was most pronounced in regions near sensorimotor cortex including the frontal and parietal areas [

Indexed as

Parkinson DiseaseSensorimotor CortexAgedAgingBasal GangliaElectroencephalographyHumansagingbeta powerGaussianParkinson’s diseasesensorimotor

Identifiers

PMID37017333
PMCPMC10151040
OpenAlexW4362601980

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.