SynthesisCirculation research2023
FHL5 Controls Vascular Disease-Associated Gene Programs in Smooth Muscle Cells.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Circulation research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Dissecting the Genetic Architecture of Intracranial Aneurysms.Circulation. Genomic and precision medicine · 2025Pooled it
- Loss of the Coronary Artery Disease Risk GeneCirculation · 2026Article
- FHL3 Regulates Vascular Smooth Muscle Cell Phenotypic Switching Through the MRTFB-SRF Signaling Axis.Cells · 2026Article
- Inflammation in atherosclerosis: Drivers, mechanisms and therapies.Acta pharmaceutica Sinica. B · 2026Review
- Targeting bromodomain and extraterminal proteins in cardiovascular disease: Pathological mechanisms and therapeutic applications.The Journal of international medical research · 2026Review
- Review
- Multimodal atlas of human atherosclerosis links granular vascular cell states to coronary artery disease risk.medRxiv : the preprint server for health sciences · 2026Article
- Vascular smooth muscle cell state trajectories mediate molecular mechanisms of coronary disease risk.Nature communications · 2026Article
- Multi-omics data integration from patients with carotid stenosis illuminates key molecular signatures of atherosclerotic instability.Genome medicine · 2026Article
- The Causal Association between Plasma Metabolites-Mediated Immune Cells and Myocardial Infarction: A Mendelian Randomization Study.Arquivos brasileiros de cardiologia · 2026Article
- GDF15 predisposes aortic dissection through regulation of vascular smooth muscle cell proliferation and phenotypic change via the ERK/Akt pathway.American journal of translational research · 2026Article
- Integrative transcriptomic and single-cell analysis reveals mitochondrial-related gene biomarkers in heart failure with preserved ejection fraction.Scientific reports · 2025Article
- Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of the RNA sensor MDA5 in atherosclerosis.Nature cardiovascular research · 2025Article
- Metabolic Atlas of Human Eyelid Infiltrative Basal Cell Carcinoma.Investigative ophthalmology & visual science · 2025Article
- A four-gene signature identified by integrated transcriptomic analysis for differential diagnosis and prognosis of uterine smooth muscle tumors.Frontiers in oncology · 2025Article
- An organotypic atlas of human vascular cells.Nature medicine · 2024Article
- Efferocytosis in atherosclerosis.Nature reviews. Cardiology · 2024Review
- Improved polygenic risk prediction in migraine-first patients.The journal of headache and pain · 2024Article
- Chronic Overlapping Pain Conditions and Nociplastic Pain.medRxiv : the preprint server for health sciences · 2024Article
- Single-Cell Analyses Offer Insights into the Different Remodeling Programs of Arteries and Veins.Cells · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 13 institutions in 7 countries.
Doris WongDepartment of Biochemistry and Molecular Genetics (D.W., C.Y., J.V.M., A.M., C.L.M.), University of Virginia, Charlottesville. A.I.
Gaëlle AugusteCenter for Public Health Genomics (D.W., G.A., A.W.T., Y.C., Y.S., R.N.P., R.A., C.Y., J.V.M., D.K., M.P., A.M., M.C., C.L.M.), University of Virginia, Charlottesville. A.I.ORCID 0000-0003-4900-6959
Christian L Lino CardenasCardiovascular Research Center, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (C.L.L.C., R.M.).ORCID 0000-0001-5491-4375
Adam W TurnerCenter for Public Health Genomics (D.W., G.A., A.W.T., Y.C., Y.S., R.N.P., R.A., C.Y., J.V.M., D.K., M.P., A.M., M.C., C.L.M.), University of Virginia, Charlottesville. A.I.
Yixuan ChenCenter for Public Health Genomics (D.W., G.A., A.W.T., Y.C., Y.S., R.N.P., R.A., C.Y., J.V.M., D.K., M.P., A.M., M.C., C.L.M.), University of Virginia, Charlottesville. A.I.
Yipei SongCenter for Public Health Genomics (D.W., G.A., A.W.T., Y.C., Y.S., R.N.P., R.A., C.Y., J.V.M., D.K., M.P., A.M., M.C., C.L.M.), University of Virginia, Charlottesville. A.I.
Lijiang MaDepartment of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology (L. Ma, J.L.M.B.), Icahn School of Medicine at Mount Sinai, New York.
R Noah PerryCenter for Public Health Genomics (D.W., G.A., A.W.T., Y.C., Y.S., R.N.P., R.A., C.Y., J.V.M., D.K., M.P., A.M., M.C., C.L.M.), University of Virginia, Charlottesville. A.I.ORCID 0000-0002-3555-0964
Redouane AherrahrouCenter for Public Health Genomics (D.W., G.A., A.W.T., Y.C., Y.S., R.N.P., R.A., C.Y., J.V.M., D.K., M.P., A.M., M.C., C.L.M.), University of Virginia, Charlottesville. A.I.ORCID 0000-0001-8148-9554
Maniselvan KuppusamyRobert M. Berne Cardiovascular Research Center (D.W., R.N.P., M. Kuppusamy, S.K.S., M.C., C.L.M.), University of Virginia, Charlottesville. A.I.
Chaojie YangDepartment of Biochemistry and Molecular Genetics (D.W., C.Y., J.V.M., A.M., C.L.M.), University of Virginia, Charlottesville. A.I.
Jose Verdezoto MosqueraDepartment of Biochemistry and Molecular Genetics (D.W., C.Y., J.V.M., A.M., C.L.M.), University of Virginia, Charlottesville. A.I.ORCID 0000-0002-2816-2250
Collin J DubeDepartment of Microbiology, Immunology, and Cancer Biology (C.J.D.), University of Virginia, Charlottesville. A.I.ORCID 0000-0002-7154-6129
Mohammad Daud KhanCenter for Public Health Genomics (D.W., G.A., A.W.T., Y.C., Y.S., R.N.P., R.A., C.Y., J.V.M., D.K., M.P., A.M., M.C., C.L.M.), University of Virginia, Charlottesville. A.I.
Meredith PalmoreCenter for Public Health Genomics (D.W., G.A., A.W.T., Y.C., Y.S., R.N.P., R.A., C.Y., J.V.M., D.K., M.P., A.M., M.C., C.L.M.), University of Virginia, Charlottesville. A.I.ORCID 0000-0003-4801-8122
Jaspreet KalraDepartment of Molecular Physiology and Biological Physics (J.K., S.K.S.), University of Virginia, Charlottesville. A.I.ORCID 0000-0002-3720-8994
Maryam KavousiDepartment of Epidemiology, Erasmus University Medical Center, the Netherlands (M. Kavousi).ORCID 0000-0001-5976-6519
Patricia A PeyserDepartment of Epidemiology, University of Michigan, Ann Arbor (P.A.P.).ORCID 0000-0002-9717-8459
Ljubica MaticDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (L. Matic, U.H.).ORCID 0000-0002-7294-9667
Ulf HedinDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (L. Matic, U.H.).ORCID 0000-0001-9212-3945
Ani ManichaikulDepartment of Biochemistry and Molecular Genetics (D.W., C.Y., J.V.M., A.M., C.L.M.), University of Virginia, Charlottesville. A.I.
Swapnil K SonkusareRobert M. Berne Cardiovascular Research Center (D.W., R.N.P., M. Kuppusamy, S.K.S., M.C., C.L.M.), University of Virginia, Charlottesville. A.I.ORCID 0000-0001-9587-9342
Mete CivelekCenter for Public Health Genomics (D.W., G.A., A.W.T., Y.C., Y.S., R.N.P., R.A., C.Y., J.V.M., D.K., M.P., A.M., M.C., C.L.M.), University of Virginia, Charlottesville. A.I.ORCID 0000-0002-8141-0284
Jason C KovacicCardiovascular Research Institute (J.C.K.), Icahn School of Medicine at Mount Sinai, New York.ORCID 0000-0003-4555-769X
Johan L M BjörkegrenDepartment of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology (L. Ma, J.L.M.B.), Icahn School of Medicine at Mount Sinai, New York.ORCID 0000-0003-1945-7425
Rajeev MalhotraCardiovascular Research Center, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (C.L.L.C., R.M.).ORCID 0000-0003-0120-4630
Clint L MillerDepartment of Biochemistry and Molecular Genetics (D.W., C.Y., J.V.M., A.M., C.L.M.), University of Virginia, Charlottesville. A.I.ORCID 0000-0003-4276-3607
Anna Needs Neuroblastoma Answers · USMACOM (United States) · USUniversity of Virginia · USKarolinska Institutet · SEMassachusetts General Hospital · USErasmus MC · NLIcahn School of Medicine at Mount Sinai · USIntegrated Cardio Metabolic Centre · SEMahindra and Mahindra Limited (India) · INMaine Farmland Trust · USUniversität Hamburg · DEUniversity of Michigan · USVictor Chang Cardiac Research Institute · AU
Funding
Multimodal genetic regulatory architecture of coronary artery diseaseR01HL148239 · NHLBI · UNIVERSITY OF VIRGINIA · PI Clint L Miller · 2019 to 2026
$4.2MThe Role of Histone Deacetylase 9 in Vascular CalcificationR01HL142809 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MALHOTRA, RAJEEV · 2018 to 2022
$4.0MThe Role of Arylsulfatase in Vascular CalcificationR01HL162928 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI PAUL STEFAN DE VRIES, Rajeev Malhotra · 2023 to 2026
$2.6MFunctional genomics investigation of pleiotropic vascular disease lociR01HL164577 · NHLBI · UNIVERSITY OF VIRGINIA · PI MILLER, CLINT L · 2022 to 2025
$2.3MNovel molecular mechanisms of vascular smooth muscle cell-mediated large and small artery calcificationK01HL164687 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Christian Lacks Lino Cardenas · 2022 to 2026
$808kEPISTATIC REGULATORY MECHANISMS OF CORONARY HEART DISEASE RISKR00HL125912 · NHLBI · UNIVERSITY OF VIRGINIA · PI MILLER, CLINT L · 2017 to 2019
$747kDefining the Role of FHL5, a Novel Hypertension Associated Gene in Smooth Muscle CellsF31HL156463 · NHLBI · UNIVERSITY OF VIRGINIA · PI WONG, DORIS · 2021 to 2022
$58kNHLBI NIH HHS F31 HL156463NHLBI NIH HHS K01 HL164687NHLBI NIH HHS R00 HL125912NHLBI NIH HHS R01 HL142809NHLBI NIH HHS R01 HL148239NHLBI NIH HHS R01 HL162928NHLBI NIH HHS R01 HL164577
Abstract
backgroundGenome-wide association studies have identified hundreds of loci associated with common vascular diseases, such as coronary artery disease, myocardial infarction, and hypertension. However, the lack of mechanistic insights for many GWAS loci limits their translation into the clinic. Among these loci with unknown functions is
methodsWe apply a multimodal approach leveraging statistical fine-mapping, epigenomic profiling, and ex vivo analysis of human coronary artery tissues to implicate
resultsWe prioritized
conclusionsTaken together, these studies provide mechanistic insights into the pleiotropic genetic associations of
Indexed as
Coronary Artery DiseaseHypertensionMyocardial InfarctionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLIM Domain ProteinsLymphohistiocytosis, HemophagocyticMyocytes, Smooth MusclePolymorphism, Single NucleotideTranscription FactorsVascular RemodelingFHL5 protein, humanLIM Domain ProteinsTranscription Factorscoronary artery diseaseepigenomicsgenome-wide association studymyocardial infarctionvascular calcification
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