Evidence map›Paper›PMID 37017068›Full record

ArticleASN neuro

Dynamic Involvement of Striatal NG2-glia in L-DOPA Induced Dyskinesia in Parkinsonian Rats: Effects of Doxycycline.

G C Nascimento, M Bortolanza, A Bribian, G C Leal-Luiz, R Raisman-Vozari, L López-Mascaraque, E Del-Bel

Abstract read
In one paragraph

Article in ASN neuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Differential Activation States of Direct Pathway Striatal Output Neurons during l-DOPA-Induced Dyskinesia Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

G C NascimentoDepartment of Oral and Basic Biology, Faculty of Odontology of Ribeirao Preto, 28133University of Sao Paulo, Sao Paulo, Brazil.
M BortolanzaDepartment of Oral and Basic Biology, Faculty of Odontology of Ribeirao Preto, 28133University of Sao Paulo, Sao Paulo, Brazil.
A BribianDepartment of Molecular, Cellular, and Developmental Neurobiology, Instituto Cajal -CSIC-, Spanish National Research Council, Madrid, Spain.
G C Leal-LuizDepartment of Oral and Basic Biology, Faculty of Odontology of Ribeirao Preto, 28133University of Sao Paulo, Sao Paulo, Brazil.
R Raisman-VozariSorbonne Université, Paris Brain Institute-ICM, 27102Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, Paris, France.
L López-MascaraqueDepartment of Molecular, Cellular, and Developmental Neurobiology, Instituto Cajal -CSIC-, Spanish National Research Council, Madrid, Spain.
E Del-BelDepartment of Oral and Basic Biology, Faculty of Odontology of Ribeirao Preto, 28133University of Sao Paulo, Sao Paulo, Brazil.ORCID 0000-0003-3483-8074

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

summary statementNG2-glia alters its dynamics in response to L-DOPA-induced dyskinesia. In these animals, striatal NG2-glia density was reduced with cells presenting activated phenotype while doxycycline antidyskinetic therapy promotes a return to NG2-glia cell density and protein to a not activated state.

Indexed as

Dyskinesia, Drug-InducedParkinsonian DisordersAnimalsAntiparkinson AgentsDisease Models, AnimalDoxycyclineLevodopaNeurogliaOxidopamineRatsRats, Sprague-DawleyAntiparkinson AgentsDoxycyclineLevodopaOxidopamineastrocyteL-DOPA-induced dyskinesiamicrogliaNG2-gliaParkinson's disease

Identifiers

PMID37017068
PMCPMC10084551

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.