Evidence map›Paper›PMID 37016991›Full record

Observational studyJournal of child neurology2023

Odds of Cardiometabolic Diseases and Medications in Children With Cerebral Palsy.

Rachel Dum, Vonn Walter, Neal J Thomas, Conrad Krawiec

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in Journal of child neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07077226 (Prevalence and Clinical Impact of Sleep-Disordered Breathing in Children With Cerebral Palsy at Increased Risk of Respiratory Disorders), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07077226 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Prevalence and Clinical Impact of Sleep-Disordered Breathing in Children With Cerebral Palsy at Increased Risk of Respiratory Disorders

TypeobservationalSponsorGUIDO CAMANNIRan2025 to 2027Enrolled150ConditionsSleep-disordered Breathing (SDB)ArmsPolysomnography
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rachel DumPennsylvania State University College of Medicine, Hershey, PA, USA.ORCID 0000-0002-9244-5765
Vonn WalterDepartment of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Neal J ThomasDepartment of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Conrad KrawiecDepartment of Pediatrics, Pediatric Critical Care Medicine, Penn State Hershey Children's Hospital, Hershey, PA, USA.ORCID 0000-0001-7902-2568

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
NCATS NIH HHS UL1 TR002014
6 · The paper itself

Abstract

INTRODUCTION/

objectivesIndividuals with cerebral palsy may be at risk of obesity, but outcomes and risk factors are understudied. The study objectives are to evaluate the frequency of body mass index (BMI) weight categories of individuals with cerebral palsy and the odds of cardiometabolic-specific diseases and medications. We hypothesize subjects with cerebral palsy and an increased body mass index will have higher odds of cardiometabolic specific diseases and medications.

methodsThis is a retrospective observational cohort study utilizing TriNetX, an electronic health record database, in subjects with cerebral palsy aged 2-18 years with an available body mass index. The study population was divided into 4 body mass index percentile categories, underweight (<5th body mass index percentile), healthy weight (≥5th to <85th percentile), overweight (≥85th to <95th percentile), and obese (≥95th percentile), and the odds of the following variables were evaluated: diagnostic codes and medication codes. We computed the odds ratio to test for associations between the body mass index categories and the variables of interest.

resultsA total of 5993 subjects were included: underweight (251, 4.2%), healthy weight (2390, 39.9%), overweight (943, 15.7%), and obese (2409, 40.2%). Obese subjects had a higher odds of asthma, diabetes mellitus, hypertension, and sleep apnea when compared to the health weight group.

conclusionsThis study found patients with cerebral palsy classified as obese had higher odds of cardiometabolic comorbidity and medication codes that influence weight. Body mass index measurements are limited in this population but may be used cautiously to evaluate the body type of children with cerebral palsy and monitor cardiometabolic-associated comorbidity occurrence.

Indexed as

Cerebral PalsyHypertensionBody Mass IndexChildCohort StudiesHumansObesityOverweightThinnessbody mass index (BMI)obesitypediatrics

Identifiers

PMID37016991
PMCPMC10213132

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.