ArticleNeurospine2023
Carbon Fiber-Reinforced Polyetheretherketone Spinal Implants for Treatment of Spinal Tumors: Perceived Advantages and Limitations.
Article in Neurospine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Carbon fiber-PEEK pedicle screw instrumentation in spinal oncology: a retrospective case series, systematic review of the literature, and cost-effectiveness analysis.Journal of neuro-oncology · 2026Pooled it
- Carbon fiber-reinforced polyetheretherketone implants versus titanium implants for spinal tumors: a systematic review and meta-analysis.Journal of neuro-oncology · 2026Pooled it
- Clinical performance of implanted devices used in surgical treatment of patients with spinal tumors: a systematic review.BMC musculoskeletal disorders · 2024Pooled it
- Comparison of Titanium and Carbon Fiber-Reinforced Polyetheretherketone Spinal Implants in Postoperative Spine Stereotactic Body Radiation Therapy: A Comprehensive Review of Current Evidence and Future Perspectives.Advances in radiation oncology · 2026Review
- Neurophysiological characteristics of carbon PEEK screws in patients with spinal metastatic disease.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Safety and efficacy of carbon fiber-reinforced polyetheretherketone implants in primary and metastatic spinal tumors: a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- Article
- Vertebral metastatic disease: A paradigm shift.Neuro-oncology advances · 2026Review
- Novel carbon fiber pedicle screw system for the treatment of lumbar degenerative disc disease: Results from a prospective, multicenter, FDA investigational device exemption study.North American Spine Society journal · 2026Article
- Carbon fiber-reinforced polyetheretherketone spinal instrumentation in pediatric spinal tumors: report of two cases and review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Review
- Electrical stimulation properties of carbon fiber versus titanium pedicle screw instrumentation: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Worldwide research on 3D printing for cancer: a dual-method analysis of bibliometrics and stratified focused thematic.International journal of surgery (London, England) · 2026Review
- Advances in Metastatic Disease Spinal Oncology: Novel Technology Without Forgetting the Fundamentals of Surgical Treatment.Neurospine · 2025Article
- Application of deformity principles in the management of spinal neoplasms: A Primer.North American Spine Society journal · 2025Article
- Local Control After Adjuvant Radiosurgery for Spinal Metastasis Treated With Decompression and Posterior Segmental Stabilization: A Comparison Between Carbon Fiber/Polyetheretherketone-Based and Metallic Implants.Advances in radiation oncology · 2025Article
- Use of Carbon Fiber Implants to Improve the Safety and Efficacy of Radiation Therapy for Spine Tumor Patients.Brain sciences · 2025Review
- Radiotherapy and surgery: can this combination be further optimized for patients with metastatic spine disease?The oncologist · 2025Review
- Case Report: Cervical carbon fiber-reinforced PEEK pedicle screw fixation with 3D custom-made template guides for spinal oncology surgery.Frontiers in surgery · 2025Article
- Role of Posterior Carbon Fiber Implants in Spine Tumor Surgery.Global spine journal · 2025Article
- Impact of instrumentation material on local recurrence: a case-matched series using carbon fiber-PEEK vs. titanium.Journal of neuro-oncology · 2025Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCarbon-fiber reinforced polyetheretherketone (CFRP)-based spinal implants are an alternative to titanium, offering less image artifact as their metallic counterparts while maintaining similar biomechanical and biocompatibility properties. Its use in the management of spinal tumors has been reported, however the perceived advantages related to improved imaging quality, radiation treatment planning, and detection of tumor recurrence have not been fully assessed.
methodsWe performed a retrospective review of medical records amongst oncologic patients treated at MD Anderson Cancer Center with CFRP implants. Histology, tumor location, construct features, time of follow-up, adjuvant radiation, recurrences, overall survival, and hardware-related complications were recorded.
resultsSixty-nine consecutive patients were assessed (22 primary tumors, 47 metastases) and the median time for follow-up was 5.4 months. Amongst the cohort, a total of 491 CFRP pedicle screws were implanted. Hardware complications were observed in 5 cases (7.04%). Adjuvant radiation was completed in 8 patients with primary tumors and 29 patients with spinal metastases. A total of 28 patients (40.5%) from the combined primary and metastatic cohorts experienced systemic disease progression, with 12 patients (17.3%) demonstrating local recurrences. Amongst primary and metastatic tumors, overall survival (p = 0.363) and rate of local recurrence (p = 0.112) were similar.
conclusionThis largest series of CFRP implants demonstrates safe and effective spinal stabilization for patients with both primary and metastatic tumors. Enhanced postoperative imaging led to minimal imaging artifacts which facilitated postoperative radiation planning and the ability to detect local recurrence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.