ReviewJournal of pain research2023
An Updated Review on the Metabolite (AM404)-Mediated Central Mechanism of Action of Paracetamol (Acetaminophen): Experimental Evidence and Potential Clinical Impact.
Review in Journal of pain research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Efficacy of intravenous acetaminophen on postoperative shivering: A meta-analysis of randomized controlled trials.Medicine · 2024Pooled it
- Monotherapy vs. combination paracetamol and tramadol for cancer-related pain in the emergency department: a comparative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Trial
- Trial
- FDA-Approved Drugs Containing Amide Functionality in the Last Five Years (2021-2025): Pharmaceutical Use, Trends and Synthetic Approaches.Medicines (Basel, Switzerland) · 2026Review
- Trigeminal neuroplasticity after pulpitis and oral administration ofparacetamol in rats.Acta odontologica latinoamericana : AOL · 2026Article
- Acetaminophen exposure in an aging population and neurodegenerative outcomes.European journal of clinical pharmacology · 2026Article
- Applications of micro/nano drug delivery systems in cancer pain management.Bioactive materials · 2026Review
- Review
- The 'Hippocratic Oath' for AI-based clinical decision support systems.BMC medical informatics and decision making · 2026Article
- Synthesis of 4-Hydroxyphenylamino-Naphthoquinones as Paracetamol-Inspired Analogs: Chemical, In Silico, and Phenotypic Pharmacological Evaluation.Pharmaceutics · 2026Article
- Target trial emulation of early acetaminophen use and mortality in critically ill stroke patients.Scientific reports · 2026Article
- Rapid Point-of-Care Assessment of Paracetamol Intoxication via an Integrated Electrochemical-Colorimetric Method.ACS omega · 2026Article
- Paracetamol and NSAIDs in Cancer Pain Management: Evidence Review and Treatment Considerations.Current treatment options in oncology · 2026Review
- Comparison of the postoperative opioid-sparing effect between preemptive and preventive intravenous acetaminophen/ibuprofen fixed-dose combination in patients undergoing robot-assisted laparoscopic radical prostatectomy: a double-blind randomized controlled trial.The Korean journal of pain · 2026Article
- Optimization of multimodal analgesic drug combinations under the concept of precision anesthesia.American journal of translational research · 2026Review
- Article
- 3D printing of acetaminophen suppository and its quality and pharmacokinetic evaluation.3D printing in medicine · 2025Article
- Therapeutic effect of WGO in reducing the toxic effect of paracetamol on blood cells and hepato-nephro activity in male rats.Open veterinary journal · 2025Article
- Correction of Post-Traumatic Neurological Deficits Using an Argon-Containing Gas Mixture in a Rat Model of Open Traumatic Brain Injury.Bulletin of experimental biology and medicine · 2025Article
- A prospective case-control study: Analysis of the analgesic effect of acetaminophen-mannitol injection after endoscopic lumbar discectomy.The Journal of international medical research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paracetamol remains the recommended first-line option for mild-to-moderate acute pain in general population and particularly in vulnerable populations. Despite its wide use, debate exists regarding the analgesic mechanism of action (MoA) of paracetamol. A growing body of evidence challenged the notion that paracetamol exerts its analgesic effect through cyclooxygenase (COX)-dependent inhibitory effect. It is now more evident that paracetamol analgesia has multiple pathways and is mediated by the formation of the bioactive AM404 metabolite in the central nervous system (CNS). AM404 is a potent activator of TRPV
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.