Evidence map›Paper›PMID 37016669›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Reduced effectiveness of repeat influenza vaccination: distinguishing among within-season waning, recent clinical infection, and subclinical infection.

Qifang Bi, Barbra A Dickerman, Huong Q Nguyen, Emily T Martin, Manjusha Gaglani, Karen J Wernli, G K Balasubramani, Brendan Flannery, Marc Lipsitch, Sarah Cobey and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 1 country.

Qifang BiUniversity of Chicago, Chicago, Illinois, USA.
Barbra A DickermanHarvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Huong Q NguyenCenter for Clinical Epidemiology & Population Health, Marshfield Clinic Research Institute, Marshfield, Wisconsin, USA.
Emily T MartinUniversity of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Manjusha GaglaniBaylor Scott & White Health, Temple, Texas, USA.
Karen J WernliKaiser Permanente Bernard J. Tyson School of Medicine, Seattle, Washington, USA.
G K BalasubramaniUniversity of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA.
Brendan FlanneryNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, US.
Marc LipsitchHarvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Sarah CobeyUniversity of Chicago, Chicago, Illinois, USA.
US Flu Vaccine Effectiveness Network Investigators
Harvard University · USUniversity of Chicago · USBaylor Scott & White Health · USKaiser Permanente · USMarshfield Clinic · USNational Center for Immunization and Respiratory Diseases · USUniversity of Michigan · USUniversity of Pittsburgh · US

Funding

COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTER: UNIVERSAL INFLUENZA VACCINE RESEARCH75N93019C00051 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRAMMER, FLORIAN · 2019 to 2025
$105.4M
Mandatory_Estimates of Vaccine Effectiveness Against Medically-Attended, PCR-Confirmed Influenza in West South Central U.S.U01IP001039 · IP · SCOTT AND WHITE MEMORIAL HOSPITAL · PI GAGLANI, MANJUSHA · 2016 to 2020
$6.5M
Accounting for Hidden Bias in Vaccine Studies: A Negative Control FrameworkR01GM139926 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHI, XU, TCHETGEN TCHETGEN, ERIC JOEL · 2021 to 2024
$1.5M
NCIRD CDC HHS U01 IP000473NCIRD CDC HHS U01 IP001039NIAID NIH HHS 75N93019C00051NIGMS NIH HHS R01 GM139926
6 · The paper itself

Abstract

Studies have reported that prior-season influenza vaccination is associated with higher risk of clinical influenza infection among vaccinees. This effect might arise from incomplete consideration of within-season waning and recent infection. Using data from the US Flu Vaccine Effectiveness (VE) Network (2011-2012 to 2018-2019 seasons), we found that repeat vaccinees were vaccinated earlier in a season by one week. After accounting for waning VE, repeat vaccinees were still more likely to test positive for A(H3N2) (OR=1.11, 95%CI:1.02-1.21) but not for influenza B or A(H1N1). We found that clinical infection influenced individuals' decision to vaccinate in the following season while protecting against clinical infection of the same (sub)type. However, adjusting for recent clinical infections did not strongly influence the estimated effect of prior-season vaccination. In contrast, we found that adjusting for subclinical infection could theoretically attenuate this effect. Additional investigation is needed to determine the impact of subclinical infections on VE.

Indexed as

immunogenicityinfection block hypothesisinfection historyinfluenzatest negative designvaccinewaning vaccine protection

Identifiers

PMID37016669
PMCPMC10071822
OpenAlexW4327861830

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.