ArticleVirology journal2023
Molecular epidemiology analysis of symptomatic and asymptomatic norovirus infections in Chinese infants.
Article in Virology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Epidemiology of Norovirus Outbreaks in Kindergartens, Primary Schools, and Junior High Schools in Xi'an, China, From October 2020 to February 2023.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Genetic diversity of norovirus in Shenzhen Based on continuous surveillance from 2016 to 2022.Frontiers in cellular and infection microbiology · 2025Article
- Noroviruses: Evolutionary Dynamics, Epidemiology, Pathogenesis, and Vaccine Advances-A Comprehensive Review.Vaccines · 2024Review
- Development and Evaluation of a Rapid GII Norovirus Detection Method Based on CRISPR-Cas12a.Polish journal of microbiology · 2024Article
- Changing predominance of norovirus strains in children with acute gastroenteritis in Shanghai, 2018-2021.Virologica Sinica · 2023Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNorovirus is a leading cause of acute gastroenteritis among children. Previous studies based on symptomatic infections indicated that mutations, rather than recombination drove the evolution of the norovirus ORF2. These characteristics were found in hospital-based symptomatic infections, whereas, asymptomatic infections are frequent and contribute significantly to transmission.
methodsWe conducted the first norovirus molecular epidemiology analysis covering both symptomatic and asymptomatic infections derived from a birth cohort study in the northern China.
resultsDuring the study, 14 symptomatic and 20 asymptomatic norovirus infections were detected in 32 infants. Out of the 14 strains that caused symptomatic infections, 12 strains were identified as GII.3[P12], and others were GII.4[P31]. Conversely, 17 asymptomatic infections were caused by GII.4[P31], two by GII.2[P16], and one by GII.4[P16]. Regardless of symptomatic and asymptomatic infections, the mutations were detected frequently in the ORF2 region, and almost all recombination were identified in the RdRp-ORF2 region. The majority of the mutations were located around the predefined epitope regions of P2 subdomain indicating a potential for immune evasion.
conclusionThe role of symptomatic as well as asymptomatic infections in the evolution of norovirus needs to be evaluated continuously.
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