ArticleScandinavian journal of trauma, resuscitation and emergency medicine2023
External validation of the PROLOGUE score to predict neurological outcome in adult patients after cardiac arrest: a prospective cohort study.
Article in Scandinavian journal of trauma, resuscitation and emergency medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prediction performance of scoring systems after out-of-hospital cardiac arrest: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Multimodal contrastive prognostication framework for early neurological outcome prediction in post-cardiac arrest patients.Scientific reports · 2026Article
- Multimodal ensemble machine learning predicts neurological outcome within three hours after out of hospital cardiac arrest.Scientific reports · 2025Article
- System for Predicting Neurological Outcomes Following Cardiac Arrest Based on Clinical Predictors Using a Machine Learning Method: The Neurological Outcomes After Cardiac Arrest Method.Neurocritical care · 2025Article
- The Prognosis After Cardiac Arrest: Evidence on the Short- and Long-Term Course.Deutsches Arzteblatt international · 2025Review
- Role of artificial intelligence in predicting neurological outcomes in postcardiac resuscitation.Annals of medicine and surgery (2012) · 2024Review
- Recovery of consciousness after acute brain injury: a narrative review.Journal of intensive care · 2024Review
- Prediction of outcomes after cardiac arrest by a generative artificial intelligence model.Resuscitation plus · 2024Article
- Post-intensive care syndrome and health-related quality of life in long-term survivors of cardiac arrest: a prospective cohort study.Scientific reports · 2024Article
- External Validation of Updated Prediction Models for Neurological Outcomes at 90 Days in Patients With Out-of-Hospital Cardiac Arrest.Journal of the American Heart Association · 2024Article
- Red blood cell distribution width for the prediction of outcomes after cardiac arrest.Scientific reports · 2023Article
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11 authors.
Funding
Abstract
backgroundThe PROLOGUE score (PROgnostication using LOGistic regression model for Unselected adult cardiac arrest patients in the Early stages) is a novel prognostic model for the prediction of neurological outcome after cardiac arrest, which showed exceptional performance in the internal validation. The aim of this study is to validate the PROLOGUE score in an independent cohort of unselected adult cardiac arrest patients and to compare it to the thoroughly validated Out-of-Hospital Cardiac Arrest (OHCA) and Cardiac Arrest Hospital Prognosis (CAHP) scores.
methodsThis study included consecutive adult cardiac arrest patients admitted to the intensive care unit (ICU) of a Swiss tertiary teaching hospital between October 2012 and July 2022. The primary endpoint was poor neurological outcome at hospital discharge, defined as a Cerebral Performance Category (CPC) score of 3 to 5 including death.
resultsOf 687 patients included in the analysis, 321 (46.7%) survived to hospital discharge with good neurological outcome, 68 (9.9%) survived with poor neurological outcome and 298 (43.4%) died. The PROLOGUE score showed an area under the receiver operating characteristic curve (AUROC) of 0.83 (95% CI 0.80 to 0.86) and good calibration for the prediction of the primary outcome. The OHCA and CAHP score showed similar performance (AUROC 0.83 and 0.84 respectively), the differences between the three scores were not significant (p = 0.495). In a subgroup analysis, the PROLOGUE score performed equally in out-of-hospital and in-hospital cardiac arrest patients whereas the OHCA and CAHP score performed significantly better in OHCA patients.
conclusionThe PROLOGUE score showed good prognostic accuracy for the early prediction of neurological outcome in adult cardiac arrest survivors in our cohort and might support early goals-of-care discussions in the ICU. Trial registration Not applicable.
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